Separation and purification method for synthetic 3-hydroxybutyrate low polymer or synthetic 3-hydroxybutyrate oligomer and application of synthetic 3-hydroxybutyrate low polymer or oligomer in antibacterial and antiviral products

Abstract

The invention discloses a separation and purification method for a synthetic 3-hydroxybutyrate low polymer or synthetic 3-hydroxybutyrate oligomer and application of the synthetic 3-hydroxybutyrate low polymer or oligomer in antibacterial and antiviral products. According to the method, an organic metal complex is utilized to catalyze the ring-opening polymerization reaction of lactone to artificially synthesize the 3-hydroxybutyrate low polymer or oligomer, the organic metal complex catalyst is precipitated from a reaction mixture by using citric acid, a precipitate is removed by using a filtration method to separate the organic metal complex catalyst from the reaction mixture, low-boiling-point organic components are removed from a filtrate by using reduced-pressure distillation, distillation temperature is raised, and a 3-hydroxybutyrate low polymer or oligomer fraction distilled out in a specific temperature range is collected, so the purified 3-hydroxybutyrate low polymer or oligomer is obtained. The purified 3-hydroxybutyrate low polymer or oligomer is used as an antibacterial and antiviral active component in medical health and cleaning products. 本发明公开了合成的3‑羟基丁酸酯低聚物或寡聚物的分离纯化方法及其在抗菌抗病毒制品方面的应用。本发明利用有机金属配合物催化内酯开环聚合反应人工合成3‑羟基丁酸酯低聚物或寡聚物，使用柠檬酸将有机金属配合物催化剂从反应混合物中沉淀出来，再利用过滤法除去沉淀以将有机金属配合物催化剂从反应混合物中分离出，然后利用减压蒸馏，从滤液中去除低沸点有机组分，再升高蒸馏温度，收集在特定温度范围下蒸出的3‑羟基丁酸酯低聚物或寡聚物馏分，从而获得纯化的3‑羟基丁酸酯低聚物或寡聚物，将其作为抗菌抗病毒活性组分用于医疗卫生和清洁制品中。