Phosphine ligand of pyrazole-amide skeleton as well as preparation method and application of phosphine ligand

Abstract

The invention discloses a phosphine ligand of a pyrazole-amide skeleton and a preparation method and application thereof, the structural formula of the phosphine ligand is shown in the specification, R1 and R2 are independently alkyl or aryl, R3 is alkyl or aryl, R4 is hydrogen, alkyl, alkoxy, aryl or fluorine, and R5 and R6 are independently alkyl or aryl. The phosphine ligand of the pyrazole-amide skeleton provided by the invention can form a complex with a stable structure with transition metal such as palladium, so that the catalytic activity of the transition metal such as palladium in a catalytic reaction is improved, and the phosphine ligand is wide in application range, good in selectivity and mild in reaction condition. 本发明公开了一种吡唑‑酰胺骨架的膦配体及其制备方法与应用，其中，膦配体的结构式如下所示：其中，所述R1、R2单独为烷基或芳基，所述R3为烷基或芳基，所述R4为氢、烷基、烷氧基、芳基或氟，所述R5、R6单独为烷基或芳基。本发明提供的吡唑‑酰胺骨架的膦配体，能与过渡金属如钯构成结构稳定的络合物，从而提高过渡金属如钯催化反应时的催化活性，而且适用范围广，选择性好，反应条件温和。