Brain-targeted nano delivery system and preparation method thereof

Abstract

The invention discloses a brain-targeted nano delivery system and a preparation method thereof. The nano delivery system comprises an inner core and a shell wrapping the inner core, wherein the inner core is made of one of a medicine and a nutrient substance; and the shell is made of zein and RVG29 combined with the surface, away from the side where the inner core is located, of the zein. The nano delivery system provided by the invention has good targeting to the brain, can prolong the preservation time of the or the nutrient substance, and improves the working stability in blood, so that the action effects of the medicine and the nutrient substance are improved, and the nano delivery system has remarkable superiority in biopharmaceutical application of brain diseases and brain development. The preparation method is simple in process, mild in preparation process condition and beneficial to wide application. 本发明公开一种脑靶向纳米递释系统及其制备方法，所述纳米递释系统包括内核和包覆所述内核的外壳，所述内核的材料包括药物和营养物质中的一种，所述外壳的材料包括玉米醇溶蛋白和结合于所述玉米醇溶蛋白远离所述内核所在侧的表面的RVG29。本发明提供的纳米递释系统在对大脑具有较好的靶向性的同时可提高药物或营养物质的保存时间，提高了在血液中工作时的稳定性，从而提高了药物和营养物质的作用效果，对于脑疾病和脑发育的生物制药应用有显著的优越性。本发明提供的制备方法工艺简单，制备过程条件温和，有利于广泛使用。