Drug-loaded material capable of monitoring and tracking drug delivery process and preparation method thereof

Abstract

A material, a drug carrier comprising the material, a drug delivery and tracking system, and a drug monitoring method are disclosed. The material comprises chitosan and glycolic acid cellulose, the chitosan and polyethyleneimine are subjected to covalent cross-linking to form cross-linked chitosan, and the cross-linked chitosan and the glycolic acid cellulose are subjected to ionic cross-linking. The drug delivery and tracking system comprising the material can realize dual-phase monitoring of release and oxidation state of the drug. 本发明公开一种材料、包含该材料的药物载体、药物递送和跟踪系统以及药物监测方法。该材料包括壳聚糖和乙醇酸纤维素，其中，所述壳聚糖与聚乙烯亚胺共价交联而形成交联的壳聚糖，所述交联的壳聚糖与所述乙醇酸纤维素离子交联。包含该材料的药物递送和跟踪系统能实现药物的释放和氧化状态的双相监测。