Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/91330
PIRA download icon_1.1View/Download Full Text
Title: Clinical evolution of ST11 carbapenem resistant and hypervirulent klebsiella pneumoniae
Authors: Xie, M
Yang, X
Xu, Q
Ye, L
Chen, K
Zheng, Z
Dong, N
Sun, Q
Shu, L
Gu, D
Chan, EWC 
Zhang, R
Chen, S
Issue Date: 2021
Source: Communications biology, 2021, v. 4, 650
Abstract: Carbapenem-resistant and hypervirulent K. pneumoniae (CR-HvKP) strains that have emerged recently have caused infections of extremely high mortality in various countries. In this study, we discovered a conjugative plasmid that encodes carbapenem resistance and hypervirulence in a clinical ST86 K2 CR-HvKP, namely 17ZR-91. The conjugative plasmid (p17ZR-91-Vir-KPC) was formed by fusion of a non-conjugative pLVPK-like plasmid and a conjugative blaKPC-2-bearing plasmid and is present dynamically with two other non-fusion plasmids. Conjugation of p17ZR-91-Vir-KPC to other K. pneumoniae enabled them to rapidly express the carbapenem resistance and hypervirulence phenotypes. More importantly, genome analysis provided direct evidence that p17ZR-91-Vir-KPC could be directly transmitted from K2 CR-HvKP strain, 17ZR-91, to ST11 clinical K. pneumoniae strains to convert them into ST11 CR-HvKP strains, which explains the evolutionary mechanisms of recently emerged ST11 CR-HvKP strains.
Publisher: Nature Publishing Group
Journal: Communications biology 
EISSN: 2399-3642
DOI: 10.1038/s42003-021-02148-4
Rights: © The Author(s) 2021
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/.
The following publication Xie, M., Yang, X., Xu, Q., Ye, L., Chen, K., Zheng, Z., ... & Chen, S. (2021). Clinical evolution of ST11 carbapenem resistant and hypervirulent Klebsiella pneumoniae. Communications biology, 4(1), 1-9 is available at https://doi.org/10.1038/s42003-021-02148-4
Appears in Collections:Journal/Magazine Article

Files in This Item:
File Description SizeFormat 
s42003-021-02148-4.pdf1.56 MBAdobe PDFView/Open
Open Access Information
Status open access
File Version Version of Record
Access
View full-text via PolyU eLinks SFX Query
Show full item record

Page views

5
Citations as of May 15, 2022

SCOPUSTM   
Citations

5
Citations as of May 12, 2022

WEB OF SCIENCETM
Citations

3
Citations as of May 12, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.