Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/74534
PIRA download icon_1.1View/Download Full Text
Title: High-frequency ultrasound imaging of tidemark in vitro in advanced knee osteoarthritis
Authors: Huang, YP 
Zhong, J 
Chen, J 
Yan, CH
Zheng, YP 
Wen, CY 
Issue Date: Jan-2018
Source: Ultrasound in medicine and biology, Jan. 2018, v. 44, no. 1, p. 94-101
Abstract: High-frequency ultrasound imaging has been widely adopted for assessment of the degenerative changes of articular cartilage in osteoarthritis (OA). Yet, there are few reports on investigating its capability to evaluate subchondral bone. Here, we employed high-frequency ultrasound imaging (25 MHz) to examine in vitro the tidemark in cylindrical osteochondral disks (n = 33) harvested from advanced OA knees of humans. We found good correspondence in morphology observed by ultrasound imaging and micro-computed tomography. Ultrasound roughness index (URI) of tidemark was derived from the raw radiofrequency signals to compare with bone quality factors, including bone volume fraction (BV/TV) and bone mineral density (BMD) measured by micro-computed tomography, using the Spearman correlation (ρ). URI of the tidemark was negatively associated with the subchondral plate BV/TV (ρ = -0.73, p <. 0.001), BMD (ρ = -0.40, p = 0.020), as well as the underneath trabecular bone BV/TV (ρ = -0.39, p = 0.025) and BMD (ρ = -0.43, p = 0.012). In conclusion, this preliminary study demonstrated that morphology measured by high-frequency ultrasound imaging could reflect the quality of the subchondral bone. High-frequency ultrasound is a promising imaging tool to evaluate the changes of the subchondral bone in addition to those of the overlying cartilage in OA.
Keywords: Articular cartilage
High-frequency ultrasound
Osteoarthritis
Roughness
Subchondral bone
Tidemark
Publisher: Elsevier
Journal: Ultrasound in medicine and biology 
ISSN: 0301-5629
EISSN: 1879-291X
DOI: 10.1016/j.ultrasmedbio.2017.08.1884
Rights: Copyright © 2018 World Federation for Ultrasound in Medicine & Biology. All rights reserved.
© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
The following publication Huang, Y. P., Zhong, J., Chen, J., Yan, C. H., Zheng, Y. P., & Wen, C. Y. (2018). High-frequency ultrasound imaging of tidemark in vitro in advanced knee osteoarthritis. Ultrasound in Medicine & Biology, 44(1), 94-101 is available at https://doi.org/10.1016/j.ultrasmedbio.2017.08.1884
Appears in Collections:Journal/Magazine Article

Files in This Item:
File Description SizeFormat 
Huang_High-frequency_Ultrasound_Imaging.pdfPre-Published version901.15 kBAdobe PDFView/Open
Open Access Information
Status open access
File Version Final Accepted Manuscript
Access
View full-text via PolyU eLinks SFX Query
Show full item record

Page views

55
Last Week
0
Last month
Citations as of Jun 26, 2022

Downloads

2
Citations as of Jun 26, 2022

SCOPUSTM   
Citations

5
Last Week
0
Last month
Citations as of Jun 30, 2022

WEB OF SCIENCETM
Citations

5
Last Week
0
Last month
Citations as of Jun 30, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.