Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/70452
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Title: Electrospun polymeric micro/nanofibrous scaffolds for long-term drug release and their biomedical applications
Authors: Zhang, Q
Li, Y
Lin, ZYW
Wong, KKY
Lin, M
Yildirimer, L
Zhao, X 
Issue Date: Sep-2017
Source: Drug discovery today, Sept. 2017, v. 22, no. 9, p. 1351-1366
Abstract: Electrospun polymeric micro/nanofibrous scaffolds have been investigated extensively as drug delivery platforms capable of controlled and sustained release of therapeutic agents in situ. Such scaffolds exhibit excellent physicochemical and biological properties and can encapsulate and release various drugs in a controlled fashion. This article reviews recent advances in the design and manufacture of electrospun scaffolds for long-term drug release, placing particular emphasis on polymer selection, types of incorporated drugs and the latest drug-loading techniques. Finally, applications of such devices in traumatic or disease states requiring effective and sustained drug action are discussed and critically appraised in their biomedical context.
Publisher: Churchill Livingstone
Journal: Drug discovery today 
ISSN: 1359-6446
EISSN: 1878-5832
DOI: 10.1016/j.drudis.2017.05.007
Rights: © 2017 Elsevier Ltd. All rights reserved.
© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
The following publication Zhang, Q., Li, Y., Lin, Z. Y. W., Wong, K. K., Lin, M., Yildirimer, L., & Zhao, X. (2017). Electrospun polymeric micro/nanofibrous scaffolds for long-term drug release and their biomedical applications. Drug Discovery Today, 22(9), 1351-1366 is available at https://doi.org/10.1016/j.drudis.2017.05.007
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