Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/2323
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Title: Suppression of diet-induced hypercholesterolemia by scutellarin in rats
Authors: Li, Q
Wu, J
Guo, D
Cheng, H
Chen, S
Chan, SW
Issue Date: Sep-2009
Source: Planta medica, Sept. 2009, v. 75, no. 11, p. 1203-1208
Abstract: Hypercholesterolemia is a major risk factor for the development and progression of cardiovascular diseases including atherosclerosis. A major active ingredient, scutellarin, from the plant Erigeron breviscapus was investigated for its hypocholesterolemic and atheroscleroprotective effects (30 and 100 mg/kg/day, p. o.). The serum lipid profile (total cholesterol, triglycerides, high density lipoprotein cholesterol and low density lipoprotein cholesterol) was monitored and aortic functions in Sprague-Dawley rats fed with normal diet, atherogenic diet or atherogenic diet plus oral administration of either scutellarin or simvastatin (a positive control) were tested. It was found that scutellarin markedly attenuated the increased serum total cholesterol induced by atherogenic diet. It caused a significant reduction in the atherogenic index. In addition, scutellarin administration could significantly enhance acetylcholine-induced nitrate/nitrite production, increase the gene expression of endothelial nitric oxide synthase and improve acetylcholine-induced endothelium-dependent vasorelaxation in rat isolated aortas. These data revealed that scutellarin could reduce the atherogenic properties of dietary cholesterol in rats. However, whether scutellarin's atheroscleroprotective potential targets endothelial function directly or indirectly on its antioxidative activity remains to be determined.
Keywords: Scutellarin
Atherosclerosis
Hypercholesterolemia
Vasorelaxation
Nitric oxide
Cholesterol
Publisher: Georg Thieme Verlag
Journal: Planta medica 
ISSN: 0032-0943
DOI: 10.1055/s-0029-1185539
Rights: Planta Medica © 2009 Georg Thieme Verlag. The journal web site is located at http://www.thieme-connect.com
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