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Title: Effects of vitamin E and pinoline on retinal lipid peroxidation
Authors: Tam, BB
Siu, AW
Lam, AF
Lee, EY
Keywords: Copper
Vitamin E
Issue Date: 2004
Publisher: Wiley-Blackwell
Source: Clinical and experimental optometry, 2004, v. 87, no. 3, p. 171-174 How to cite?
Journal: Clinical and experimental optometry 
Abstract: Background: Pinoline is a pineal indoleamine naturally found in the retina. This study compared the effects of pinoline and vitamin E on the copper (I)-induced retinal lipid peroxidation (LPO). Methods: Porcine retinal homogenates were mixed with 120 μM copper (I) solution. The mixtures were co-incubated with various concentrations of pinoline or trolox (water-soluble vitamin E analogue) at 37 degrees Centigrade for 60 minutes. The amounts of malondialdehyde (MDA) and protein were assayed to quantify the LPO. Results: Copper (I) ions significantly increased the MDA concentration in the retinal homogenates (p < 0.0007). Both pinoline and trolox significantly suppressed MDA in a dose-dependent manner (p < 0.0001) and their effects were significantly different (p = 0.004). The concentrations that inhibited 50 per cent of LPO were 0.24 mM and 0.68 mM for pinoline and trolox, respectively. Discussion: Pinoline suppressed the LPO at a potency of 2.8 times compared with trolox. The results support an anti-oxidative role for pinoline in the retina. Further study is required to characterise the pharmacological potency of pinoline in vivo.
ISSN: 0816-4622
EISSN: 1444-0938
DOI: 10.1111/j.1444-0938.2004.tb03170.x
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