Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/9832
Title: Development of hydrocortisone succinic acid/and 5-fluorouracil/chitosan microcapsules for oral and topical drug deliveries
Authors: Lam, PL
Lee, KKH
Wong, RSM
Cheng, GYM
Cheng, SY
Yuen, MCW
Lam, KH
Gambari, R
Kok, SHL
Chui, CH
Keywords: 5-Fluorouracil
Chitosan
Drug delivery
Hydrocortisone succinic acid
Microcapsule
Issue Date: 2012
Publisher: Pergamon Press
Source: Bioorganic & medicinal chemistry letters, 2012, v. 22, no. 9, p. 3213-3218 How to cite?
Journal: Bioorganic & medicinal chemistry letters 
Abstract: Recently, we demonstrated the safety use of calendula oil/chitosan microcapsules as a carrier for both oral and topical deliveries. We also reported the improved biological activity towards skin cells and Staphylococcus aureus of phyllanthin containing chitosan microcapsules. However, the possibility of both oral and topical applications was still necessary to be further studied. Here we investigated that both oral and topical applications of chitosan-based microcapsules were tested using hydrocortisone succinic acid (HSA) and 5-fluorouracil (5-FU), respectively. The drug loading efficiency, particle size, surface morphology and chemical compositions of both drug loaded microcapsules were confirmed by UV-vis spectrophotometer, particle size analyzer, scanning electron microscope and Fourier transform infrared spectroscopy. The in vitro release studies revealed that both HSA and 5-FU could be released form chitosan microcapsules. The mean adrenocorticotropic hormone concentration in HSA loaded microcapsule mice plasma was detected to be lower than that of water control. One hundred micrograms per milliliter of 5-FU containing microcapsules exhibited a stronger growth inhibition towards skin keratinocytes than that of free 5-FU. In vitro drug delivery model demonstrated the delivery of 5-FU from microcapsule treated textiles into nude mice skin. Further uses of the drug loaded microcapsules may provide an efficiency deliverable tool for both oral and topical applications.
URI: http://hdl.handle.net/10397/9832
ISSN: 0960-894X
EISSN: 1464-3405
DOI: 10.1016/j.bmcl.2012.03.031
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