Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/9800
Title: Effects of photoactivated 5-aminolevulinic acid hexyl ester on MDR1 over-expressing human uterine sarcoma cells
Authors: Chu, ESM
Yow, CMN
Shi, M
Ho, RJY
Issue Date: 2008
Publisher: Elsevier Ireland Ltd
Source: Toxicology letters, 2008, v. 181, no. 1, p. 7-12 How to cite?
Journal: Toxicology letters 
Abstract: The role of multi-drug resistance (MDR1) and its product, P-glycoprotein (P-gp) on 5-aminolevulinic acid hexyl ester (Hexyl-ALA) mediated phototoxicity was determined with human uterine sarcoma cells, MES-SA control and MDR1 expressing MES-SA-Dx5. MDR1 expression reduced intracellular levels of the Hexyl-ALA metabolite, protoporphyrin IX (PpIX) to a limited degree and could be reversed with a P-gp inhibitor, verapamil. P-gp expression also reduced Hexyl-ALA photosensitivity. More importantly, photoactivated Hexyl-ALA reduced at the mRNA and protein levels without altering housekeeping GAPDH mRNA. These findings suggest that Hexyl-ALA could be used to selectively reduce P-gp expression in overcoming resistance to chemotherapy agents such as doxorubicin and paclitaxel.
URI: http://hdl.handle.net/10397/9800
ISSN: 0378-4274
DOI: 10.1016/j.toxlet.2008.06.860
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