Please use this identifier to cite or link to this item:
Title: Heme oxygenase microsatellite polymorphism, oxidative stress, glycemic control, and complication development in type 2 diabetes patients
Authors: Choi, SW
Yeung, VTF
Benzie, IFF 
Issue Date: 2012
Source: Free radical biology and medicine, 2012, v. 53, no. 1, p. 60-63
Abstract: Heme oxygenase-1 (HMOX-1) is activated by oxidative stress, and gene responsiveness is reportedly determined by the number of dinucleotide (GT(n)) repeats in its highly polymorphic promoter region. Short (S; GT(n)<25) alleles reportedly associate with higher response, lower oxidative stress, lower risk of type 2 diabetes mellitus (type 2 DM), and better glycemic control and outcome, but data are conflicting. We investigated GT(n) in type 2 DM subjects (all ethnic Chinese) in relation to basal glycemic control, oxidative stress, and outcome during up to 9 years follow-up. Fasting blood from 418 type 2 DM subjects was collected at entry for GT(n) genotyping, glycated hemoglobin, glucose, lipids, and biomarkers of oxidative stress and antioxidants. A subset (n=368) was followed for up to 9 years for incident complications or death. GT(n) genotype distribution was 128, 182, and 108 for, respectively, S/S, S/L, and L/L. No significant differences in glycemic control, lipids, or oxidative stress were seen across genotypes. During follow-up, 168/368 subjects developed complications. No association was seen with GT(n). No difference in plasma HO-1 was seen between genotypes in a small substudy (S/S n=21 vs L/L n=23). Glycated hemoglobin and lymphocytic DNA damage was higher (p<0.05) at entry in the incident complications group. No other significant differences were seen in oxidative stress or antioxidants. Data do not support the postulated link between HMOX-1 microsatellite polymorphism and type 2 DM or the putative beneficial effect of the S allele on glycemic control, oxidative stress, or outcome in type 2 DM patients, at least in this particular population.
Keywords: Diabetic complications
Free radicals
GT repeats
Heme oxygenase-1
Oxidative stress
Type 2 diabetes
Publisher: Pergamon Press
Journal: Free radical biology and medicine 
ISSN: 0891-5849
DOI: 10.1016/j.freeradbiomed.2012.04.017
Appears in Collections:Journal/Magazine Article

View full-text via PolyU eLinks SFX Query
Show full item record


Last Week
Last month
Citations as of Sep 2, 2020


Last Week
Last month
Citations as of Sep 17, 2020

Page view(s)

Last Week
Last month
Citations as of Sep 14, 2020

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.