Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/9795
Title: Heme oxygenase microsatellite polymorphism, oxidative stress, glycemic control, and complication development in type 2 diabetes patients
Authors: Choi, SW
Yeung, VTF
Benzie, IFF 
Keywords: Diabetic complications
Free radicals
GT repeats
Heme oxygenase-1
Oxidative stress
Type 2 diabetes
Issue Date: 2012
Publisher: Pergamon Press
Source: Free radical biology and medicine, 2012, v. 53, no. 1, p. 60-63 How to cite?
Journal: Free radical biology and medicine 
Abstract: Heme oxygenase-1 (HMOX-1) is activated by oxidative stress, and gene responsiveness is reportedly determined by the number of dinucleotide (GT(n)) repeats in its highly polymorphic promoter region. Short (S; GT(n)<25) alleles reportedly associate with higher response, lower oxidative stress, lower risk of type 2 diabetes mellitus (type 2 DM), and better glycemic control and outcome, but data are conflicting. We investigated GT(n) in type 2 DM subjects (all ethnic Chinese) in relation to basal glycemic control, oxidative stress, and outcome during up to 9 years follow-up. Fasting blood from 418 type 2 DM subjects was collected at entry for GT(n) genotyping, glycated hemoglobin, glucose, lipids, and biomarkers of oxidative stress and antioxidants. A subset (n=368) was followed for up to 9 years for incident complications or death. GT(n) genotype distribution was 128, 182, and 108 for, respectively, S/S, S/L, and L/L. No significant differences in glycemic control, lipids, or oxidative stress were seen across genotypes. During follow-up, 168/368 subjects developed complications. No association was seen with GT(n). No difference in plasma HO-1 was seen between genotypes in a small substudy (S/S n=21 vs L/L n=23). Glycated hemoglobin and lymphocytic DNA damage was higher (p<0.05) at entry in the incident complications group. No other significant differences were seen in oxidative stress or antioxidants. Data do not support the postulated link between HMOX-1 microsatellite polymorphism and type 2 DM or the putative beneficial effect of the S allele on glycemic control, oxidative stress, or outcome in type 2 DM patients, at least in this particular population.
URI: http://hdl.handle.net/10397/9795
ISSN: 0891-5849
DOI: 10.1016/j.freeradbiomed.2012.04.017
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