Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/97802
| Title: | Chiral cyclen compounds and their uses | Authors: | Law, GL Dai, L |
Issue Date: | 14-Jun-2022 | Source: | US Patent US11,357,873 B2. Washington, DC: US Patent and Trademark Office, 2022. | Abstract: | The present invention relates to the preparation of a series of chiral DOTA, DO3A, DO2A, DO1A, cyclen and their metal complexes, which display properties superior to those of previous DOTA-based compounds, and hence are potentially valuable as a platform for diagnostic applications. The chiral DOTAs reveal a high abundance of twisted square antiprism (TSA) geometry favoring them to be used as potential MRI contrast agents, whereas their rapid labelling properties at mild conditions make them excellent candidates for use as radiometal chelators. | Rights: | Assignee: The Hong Kong Polytechnic University |
| Appears in Collections: | Patent |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| us11357873b2.pdf | 4.28 MB | Adobe PDF | View/Open |
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