Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/9766
Title: In vitro cytotoxicity of (-)-EGCG octaacetate on MDAMB-231 and SKHep-1 human carcinoma cells : a pharmacological consideration on prodrug design
Authors: Kok, SHL
Wong, RSM
Gambari, R
Cheung, F
Lam, WS
Lau, FY
Cheng, GYM
Cheng, CH
Lam, KH
Chan, SH
Tang, JCO 
Chui, CH
Ho, KP
Keywords: (-)-EGCG
(-)-EGCG octaacetate prodrug
Acetate
Issue Date: 2008
Publisher: Spandidos Publications
Source: International journal of molecular medicine, 2008, v. 22, no. 6, p. 841-845 How to cite?
Journal: International journal of molecular medicine 
Abstract: Esterification of acetate with generic pharmaceutical compound has been commonly employed to produce ester prodrug for improving its potency when compared with the mother compound. Acetate, on the other hand, has been recognized to have inhibitory effect on the respiratory biochemistry. Here we demonstrate that acetate at a concentration of 400 ?gM exhibited significant growth inhibitory activity on two human cancer cell lines, the MDAMB-231 breast cancer and the SKHep-1 hepatoma cell lines. To establish the ester prodrug with multi-acetate ester conjugates as our experimental model, one molecule of (-)-epigallocatechin gallate was required to conjugate with eight molecules of acetate forming the corresponding (-)-epigallocatechin gallate octaacetate prodrug. Chemical structure of this epigallocatechin gallate octaacetate ester prodrug was confirmed by
URI: http://hdl.handle.net/10397/9766
ISSN: 1107-3756
EISSN: 1791-244X
DOI: 10.3892/ijmm_00000093
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

6
Last Week
0
Last month
0
Citations as of Oct 19, 2017

WEB OF SCIENCETM
Citations

4
Last Week
0
Last month
0
Citations as of Oct 23, 2017

Page view(s)

49
Last Week
2
Last month
Checked on Oct 22, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.