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Title: | Botulinum neurotoxin type A substrate-type polypeptide inhibitor and screening method thereof | Other Title: | A型肉毒神经毒素底物型多肽抑制剂及其筛选方法 | Authors: | Chen, S Guo, J |
Issue Date: | 27-Oct-2020 | Source: | 中国专利 ZL 201510623351.2 | Abstract: | The invention is suitable for the field of biotechnology application, and provides a botulinum neurotoxin type A substrate-type polypeptide inhibitor, the polypeptide inhibitor is a combination area and an active area containing a botulinum neurotoxin type A substrate, the polypeptide inhibitor is one of R1, R2, R197C, and R1-RXF, wherein, the R1-RXF comprises R1-RGF, and R1-RAF, R1-RFF, R1-RIF, R1-RLF, R1-RPF and R1-RWF obtained by respectively substituting G by A, F, I, L, P or W in a R1-RGF amino acid sequence. 本发明适用于生物技术应用研究领域,提供了一种A型肉毒神经毒素底物型多肽抑制剂,所述多肽抑制剂为同时含有靶向A型肉毒神经素上的底物结合区域和活性区域,且所述多肽抑制剂为R1、R2、R197C、R1-RXF中的一种,其中,所述R1-RXF包括R1-RGF和所述R1-RGF氨基酸序列中的G被A、F、I、L、P或W中的一个替代后分别获得的R1-RAF、R1-RFF、R1-RIF、R1-RLF、R1-RPF和R1-RWF。 |
Publisher: | 中华人民共和国国家知识产权局 | Rights: | Assignee: 香港理工大学深圳研究院 |
Appears in Collections: | Patent |
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ZL201510623351.2.PDF | 1.51 MB | Adobe PDF | View/Open |
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