Ionic tags for synthesis of oligoribonucleotides

Abstract

The invention relates to the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. In another aspect, the invention relates to compounds of formula (II) processes for making these compounds, and the use thereof in the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. The invention also relates to methods of synthesis of oligomers, including but not limited to oligopeptides, oligosaccharides and oligonucleotides, particularly oligoribonucleotides and also oligodeoxyribonucleotides, in solution systems, and ionic tag linkers for use in methods provided herein. 本发明涉及寡核苷酸如寡核糖核苷酸的化学合成。在另一个方面，本发明涉及化学式(II)的化合物，用于制备这些化合物的方法，以及其在寡核苷酸如寡核糖核苷酸的化学合成中的应用。本发明还涉及用于在溶液体系中合成寡聚物的方法，包括但不限于寡肽、寡糖和寡核苷酸，尤其是寡核糖核苷酸以及寡脱氧核糖核苷酸，以及用于本文提供的方法中的离子标记接头。