Vitamin D supplementing preparation and application thereof

Abstract

The invention belongs to the technical field of biological medicine, and particularly relates to a vitamin D supplementing preparation and application thereof. The vitamin D supplementing preparationcomprises the following active ingredients: calcifediol and oleanolic acid. The calcitriol and the oleanolic acid have a synergistic effect, so that bone marrow stem cells and osteoblasts can be effectively promoted to express CYP27B1, the synthesis of 1,25-dihydroxy vitamin D3 is improved, vitamin D3 required by human bodies, particularly special crowds, can be quickly supplemented, calcium and phosphorus metabolism can be regulated, bone mineral deposition can be promoted, and the vitamin D supplementing preparation can be applied to preparation of medicines for preventing or treating bone diseases caused by vitamin D deficiency. 本发明属于生物医药技术领域，具体涉及一种维生素D补充制剂及其应用。本发明所提供的维生素D补充制剂，其活性成分包括：骨化二醇和齐墩果酸。骨化二醇和齐墩果酸协同作用，可有效促进骨髓干细胞和成骨细胞表达CYP27B1，提高1,25‑二羟基维生素D3的合成，可快速补充人体尤其是特殊人群所需的维生素D3，调节钙磷代谢，促进骨矿物质沉积，可应用于制备预防或治疗由维生素D缺乏引起的骨性疾病。