Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/9498
Title: Transfer of collagen coating from porogen to scaffold : collagen coating within poly(dl-lactic-co-glycolic acid) scaffold
Authors: Li, J
Mak, AFT
Keywords: A. Foams
A. Polymer-matrix composites (PMCs)
Collagen
E. Surface treatments
Issue Date: 2007
Publisher: Pergamon Press
Source: Composites. Part B, Engineering, 2007, v. 38, no. 3, p. 317-323 How to cite?
Journal: Composites. Part B, Engineering 
Abstract: Using paraffin micro-spheres as porogen, this paper addressed a novel method to coat collagen onto the internal pore surface within poly(dl-lactic-co-glycolic acid) (PLGA) scaffold with controlled pore size. The paraffin micro-spheres with desirable size were mixed with collagen solution (0.5-1.0% w/v), molded to form a paraffin micro-sphere scaffold, and dried. The collagen was left on the surface of the paraffin micro-spheres and even among the paraffin micro-spheres. PLGA solution was then cast into the interspace of the paraffin/collagen scaffold and dried. After the paraffin micro-spheres were dissolved and removed, PLGA scaffold with controlled pore size, good interconnectivity and high porosity was obtained. Collagen was transferred from the paraffin micro-spheres to the surfaces of the pore wall. Observation of scanning electron microscopy (SEM) showed that collagen was coated on the paraffin micro-spheres and was on the surfaces of pore wall within PLGA scaffold. Fourier transform infrared spectroscopy (FTIR) also detected the presence of collagen in the PLGA scaffold so formed; and there was no apparent change on the molecular components of collagen during the experimental procedure.
URI: http://hdl.handle.net/10397/9498
ISSN: 1359-8368
EISSN: 1879-1069
DOI: 10.1016/j.compositesb.2006.06.009
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