Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/9471
Title: Efficient cyanation of aryl bromides with K-4[Fe(CN)(6)] catalyzed by a palladium-indolylphosphine complex
Authors: Yeung, PY
Tsang, CP
Kwong, FY 
Issue Date: 2011
Publisher: Pergamon Press
Source: Tetrahedron letters, 2011, v. 52, no. 52, p. 7038-7041 How to cite?
Journal: Tetrahedron letters 
Abstract: This study describes a general palladium-catalyzed cyanation of aryl bromides using K-4[Fe(CN)(6)] as the cyanide surrogate. The reactions can be successfully conducted under mild reaction conditions (at 50 degrees C) in mixed solvents (water/MeCN = 1:1) without any surfactant additives, and afford the desired aryl nitriles in good-to-excellent yields. Particularly noteworthy is that this system allows the mildest reaction temperature reported so far for palladium-catalyzed cyanation of aryl bromides with K-4[Fe(CN)(6)] source in general. Common functional groups, including keto, aldehyde, free amine, and heterocyclic substrates are compatible under this system. Interestingly, the phosphine ligands bearing -PCy2 moiety, which usually show excellent activity in aryl halide couplings, are found less effective than the corresponding ligands with -PPh2 group.
URI: http://hdl.handle.net/10397/9471
ISSN: 0040-4039
EISSN: 1873-3581
DOI: 10.1016/j.tetlet.2011.09.088
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