Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/9010
Title: The time effect of pressure on tissue viability : investigation using an experimental rat model
Authors: Kwan, MPC
Tam, EWC 
Lo, SCL 
Leung, MCP
Lau, RYC
Keywords: Histological evaluation
Hyperemia
Laser doppler flowmetry
Pressure ulcer
Tibia
Trochanter
Issue Date: 2007
Publisher: Society for Experimental Biology and Medicine
Source: Experimental biology and medicine, 2007, v. 232, no. 4, p. 481-487 How to cite?
Journal: Experimental biology and medicine 
Abstract: An experimental rat model was used to investigate the time-pressure effect on tissue viability. External loading equivalent to 13.3 kPa (100 mm Hg) of pressure was applied to the greater trochanter and tibialis area of Sprague-Dawley rats using pneumatic indentors for duration of 6 hrs each day for 1 to 4 days. It was observed that postocclusive hyperemic responses were gradually increased at the trochanter throughout the 4 days of loading, whereas for the tibia there was a significant increase (P = 0.04) in postocclusive hyperemic flow between Days 2 and 3. In histologic evaluations, cutaneous tissue damage was observed at the trochanter area but not at the tibialis area after 2 consecutive days of load application. In contrast, degeneration of muscle cells characterized by numerous increases of nuclei occupying the central of the muscle fibers was observed after 2 days of load application at the tibialis. The situation was found to progress with time (P = 0.17). The presence of other histologic signs, including the internalization of peripherally located nuclei, replacement of muscle cells by fibrosis and adipose tissues, and the presence of pyknotic nuclei as well as karyorrhexis, confirmed that the affected tissues were damaged. These findings suggest that postocclusive hyperemia and the distress of tissues under loading could be closely related.
URI: http://hdl.handle.net/10397/9010
ISSN: 1535-3702
EISSN: 1535-3699
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