Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/88901
PIRA download icon_1.1View/Download Full Text
DC FieldValueLanguage
dc.contributorDepartment of Health Technology and Informatics-
dc.creatorWu, WV-
dc.creatorYing, MT-
dc.creatorKwong, DL-
dc.creatorWong, GK-
dc.creatorKhong, P-
dc.date.accessioned2021-01-11T02:42:21Z-
dc.date.available2021-01-11T02:42:21Z-
dc.identifier.issn0167-8140-
dc.identifier.urihttp://hdl.handle.net/10397/88901-
dc.description38th Annual Meeting of the European-Society-for-Radiotherapy-and-Oncology (ESTRO), Apr 26-30, 2019, Milan, ITALYen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rightsUnder a Creative Commons license. Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) (https://creativecommons.org/licenses/by-nc-nd/4.0/)en_US
dc.rightsThe following publication Wu, W. V., Ying, M. T., Kwong, D. L., Wong, G. K., & Khong, P. (2019). Early radiation induced changes in salivary glands in nasopharyngeal cancer patients after IMRT. Radiotherapy and Oncology, 133, EP-1168, S646 is available at https://dx.doi.org/10.1016/S0167-8140(19)31588-9en_US
dc.titleEarly radiation induced changes in salivary glands in nasopharyngeal cancer patients after IMRTen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spageS646-
dc.identifier.volume133-
dc.identifier.doi10.1016/S0167-8140(19)31588-9-
dcterms.abstractPurpose or Objective Parotid and submandibular glands are the main source of saliva. Both glands are irradiated to high dose by radical external beam radiotherapy (EBRT) in nasopharyngeal cancer (NPC) patients. Xerostomia is one of the common radiation induced complications in NPC patients caused by damaged of parotid and submandibular glands after RT.Persistent xerostomia causes difficulties in mastication and swallowing and enhances the risks of dental problems. The aims of this study were to assess the changes of the salivary glands after 6 months of post-RT using magnetic resonance imaging (MRI), ultrasonography (US), saliva flow rate and contents.-
dcterms.abstractMaterial and Methods 25 NPC patients with stage I to III (UICC) treated by routine EBRT using 6 MV 9-field intensity modulated radiotherapy and with no previous history of salivary glands disorder were recruited. Each subject underwent US and MRI examinations, saliva test before the start of radiotherapy (RT) and at 6 months after RT. The US assessment was conducted by the same operator in which the haemodynamics including the blood flow velocity and vascular resistance of the salivary glands were measured. The MRI, which was performed using T1 and T2 axial and sagittal scans with slice thickness of 3 mm, provided the salivary glands’ morphological information. The saliva test included the measurement of mean saliva flow rate (SFR) and the main contents of the saliva including alphaamylase and immunoglobulin A (IgA). The mean values of each measured parameters were calculated and paired ttest was conducted to assess their differences between the two time intervals.-
dcterms.abstractResults The mean volumes of parotid and submandibular glands were significantly reduced by about 30% at 6- month after RT (p <0.001). The two glands also demonstrated lower vascular velocity, resistive and pulsatility indices (p <0.05) when compared to the pre-RT condition. This indicated that the blood flow in the post-RT glands was slower and the blood vessels experienced lower pressure than those of the post-RT. In addition, the post-RT mean SFR was reduced by more than 9 times when compared with that in pre-RT (p < 0.001). The levels of the salivary alpha amylase and IgA were also significantly reduced at the 6-month post-RT interval.-
dcterms.abstractConclusion Our study demonstrated that there were substantive impacts on the physiological and morphological aspects of the salivary glands after radical EBRT in NPC patients. The side effects were relatively early in which most measured parameters demonstrated significant changes at 6-month post-RT interval.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationRadiotherapy and oncology, 2019, v. 133, suppl. 1 , EP-1168, p. S646 (Meeting Abstract)-
dcterms.isPartOfRadiotherapy and oncology-
dcterms.issued2019-04-
dc.identifier.isiWOS:000468315603131-
dc.relation.conferenceEuropean-Society-for-Radiotherapy-and-Oncology. Annual Meeting [ESTRO. Annual Meeting]-
dc.identifier.artnEP-1168-
dc.description.validate202101 bcrc-
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_Scopus/WOSen_US
dc.description.pubStatusPublisheden_US
Appears in Collections:Journal/Magazine Article
Files in This Item:
File Description SizeFormat 
Wu_Early_Radiation_Changes.pdf122.43 kBAdobe PDFView/Open
Open Access Information
Status open access
File Version Version of Record
Access
View full-text via PolyU eLinks SFX Query
Show simple item record

Page views

61
Last Week
0
Last month
Citations as of Mar 24, 2024

Downloads

13
Citations as of Mar 24, 2024

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.