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Title: | Changes of refractive errors in children with different initial predicted myopia progression rates after 6-month 0.01% atropine treatment | Authors: | Chan, HHL Yu, WY Li, SZC Choi, KY Chan, J Choy, BNK Ng, ALK |
Issue Date: | Jun-2020 | Source: | Investigative ophthalmology and visual science, June 2020, v. 61, no. 7, special issue, 562, p. 1 (Meeting Abstract) | Abstract: | Purpose : To investigate the 6-month treatment effect of 0.01% atropine on myopic changes in children with different initial predicted myopia progression rates (PMPR) measured by global flash multifocal ERG (mfERG) Methods : 24 children aged 8 to 9 years were randomly assigned to the treatment group (T, n=12) of 0.01% atropine and the control group (C, n=12) of artificial tears. Cycloplegic objective refraction (SER), axial length (AL) measurement and mfERG were performed at baseline and after 6 months of daily treatment. Central mfERG response from the tested eye of each subject at baseline was analyzed to determine the PMPR according to our previous study (DOI:10.1167/iovs.16-21279). The changes in refractive errors and axial length of the tested eye were calculated and compared within group and between groups by Mann-Whitney U test. Results : After 6-month atropine treatment, group T showed a mean change of -0.12D in SER and 0.15mm in AL, while group C had a change of -0.44D and 0.21mm. There was a significant difference in SER between groups (p=0.03). There were 4 and 8 subjects with slow and fast PMPR respectively in group T; while 3 and 9 subjects with slow and fast PMPR respectively in group C. Those with slow PMPR in group T and C showed similar mean change of myopia progression (T: DSER=-0.31D; DAL=0.18mm; C: DSER=-0.33D; DAL=0.21mm). However, those with fast PMPR in group T showed a significant less myopia change as compared those in group C (T: DSER=-0.06D; DAL=0.18mm; C: DSER=-0.47D; DAL=0.22mm, p=0.02 for SER). Conclusions : The 6-month 0.01% atropine treatment was shown to be effective in reducing myopia progression for the children who have fast PMPR measured by mfERG, but not for those who had slow predicted rate. |
Publisher: | Association for Research in Vision and Ophthalmology | Journal: | Investigative ophthalmology and visual science | ISSN: | 0146-0404 | EISSN: | 1552-5783 | Description: | ARVO 2020 : Association for Research in Vision & Ophthalmology Annual Meeting, May 3, 2020 - May 7, 2020, Baltimore, MD, US | Rights: | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/). The following publication Henry Ho-lung Chan, W.Y. Yu, S.Z.C. Li, K.Y. Choi, Jonathan Chan, Bonnie Nga Kwan Choy, A.L.K. Ng; Changes of refractive errors in children with different initial predicted myopia progression rates after 6-month 0.01% atropine treatment. Invest. Ophthalmol. Vis. Sci. 2020;61(7):562 is available at https://iovs.arvojournals.org/article.aspx?articleid=2766625 |
Appears in Collections: | Conference Paper |
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