Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/8767
Title: Pathophysiological mechanism of seasonal affective disorder
Authors: Lee, TMC
Blashko, CA
Janzen, HL
Paterson, JG
Chan, CCH 
Issue Date: 1997
Source: Journal of affective disorders, 1997, v. 46, no. 1, p. 25-38 How to cite?
Journal: Journal of Affective Disorders 
Abstract: Despite the long history in medicine, the pathophysiological mechanism(s) of seasonal affective disorder (SAD) remain largely unknown. By employing a meta-analytic methodology, the authors of this study attempted to verify the validity of different pathophysiological mechanism(s) proposed for SAD. The findings showed that for phototherapy of medium light intensity, a combination of morning-evening therapy regime yielded the best therapeutic effect, and the antidepressant effect of the morning-evening light regime was superior to a single pulse of light administered at other times of day. Furthermore, the data showed that the antidepressant effect of a single pulse of light was similar for morning, midday, and evening light. These findings supported the photon-count hypothesis and refuted the proposed photoperiod, melatonin, and phase-shifting models of SAD.
URI: http://hdl.handle.net/10397/8767
ISSN: 0165-0327
DOI: 10.1016/S0165-0327(97)00076-1
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