Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/8682
Title: Highly efficient and enantioselective hydrogenation of quinolines and pyridines with Ir-Difluorphos catalyst
Authors: Tang, W
Sun, Y
Xu, L
Wang, T
Fan, Q
Lam, KH
Chan, ASC
Issue Date: 2010
Publisher: Royal Society of Chemistry
Source: Organic & biomolecular chemistry, 2010, v. 8, no. 15, p. 3464-3471 How to cite?
Journal: Organic & biomolecular chemistry 
Abstract: The combination of the readily available chiral bisphosphine ligand Difluorphos with [Ir(COD)Cl]2 in THF resulted in a highly efficient catalyst system for asymmetric hydrogenation of quinolines at quite low catalyst loadings (0.05-0.002 mol%), affording the corresponding products with high enantioselectivities (up to 96%), excellent catalytic activities (TOF up to 3510 h-1) and productivities (TON up to 43000). The same catalyst was also successfully applied to the asymmetric hydrogenation of trisubstituted pyridines with nearly quantitative yields and up to 98% ee. In these two reactions, the addition of I2 additive is indispensable; but the amount of I2 has a different effect on catalytic performance.
URI: http://hdl.handle.net/10397/8682
ISSN: 1477-0520
EISSN: 1477-0539
DOI: 10.1039/c002668a
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