Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/8639
Title: Microencapsulation of puerarin nanoparticles by poly(l-lactide) in a supercritical CO2 process
Authors: Chen, AZ
Li, Y
Chau, FT
Lau, TY
Hu, JY
Zhao, Z
Mok, DKW 
Keywords: Biomaterials
Microencapsulation
Poly(l-lactide)
Puerarin
Supercritical CO2
Issue Date: 2009
Publisher: Elsevier Sci Ltd
Source: Acta biomaterialia, 2009, v. 5, no. 8, p. 2913-2919 How to cite?
Journal: Acta Biomaterialia 
Abstract: Puerarin nanoparticles were firstly prepared in the process of solution-enhanced dispersion by supercritical CO2 (SEDS) and then successfully microencapsulated by poly(l-lactide) (PLLA) in a modified SEDS process. By adding an organic non-solvent, an initial puerarin solution with a higher degree of saturation and lower concentration was obtained and applied in the SEDS process. The resulting puerarin nanoparticles were then suspended in PLLA solution and microencapsulated by PLLA in a modified SEDS process, where an 'injector' was employed in the particle suspension delivery system. The puerarin nanoparticles exhibited a good spherical shape, a smooth surface and a narrow particle size distribution with a mean particle size of 188 nm. After microencapsulation the puerarin-PLLA microparticles had a mean size of 675 nm, a drug load of 23.6% and an encapsulation efficiency of 39.4%; after a burst release at the first stage, the drug was released in a sustained process. Compared with the parallel study of a co-precipitation process, this microencapsulation process is a much more promising technique to prepare a drug-polymer carrier for a drug delivery system, especially for protein drugs.
URI: http://hdl.handle.net/10397/8639
DOI: 10.1016/j.actbio.2009.04.032
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