Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/8602
Title: Effects by doxorubicin on the myocardium are mediated by oxygen free radicals
Authors: Xu, MF
Tang, PL
Qian, ZM
Ashraf, M
Keywords: β-Adrenergic Receptor
Doxorubicin
Lipid Peroxidation
Melatonin
Membrane Permeability
Reactive Oxygen Species
Issue Date: 2001
Publisher: Pergamon-Elsevier Science Ltd
Source: Life sciences, 2001, v. 68, no. 8, p. 889-901 How to cite?
Journal: Life Sciences 
Abstract: We hypothesized that doxorubicin (DOX) induces cardiotoxicity of myocardium via oxygen radicals. The present study is aimed at examining the membrane alterations by oxygen radicals generated by DOX in adult rats and cultured neonatal myocytes. Our results showed that DOX 1) decreased β-adrenoceptor (BAR) density in the cell membrane, 2) increased the membrane permeability of cultured neonatal rat myocytes and 3) altered the ultrastructure of myofibrils and subplasmalemmal actin networks. These effects were reproducible by exogenous hydrogen peroxide. The antioxidant melatonin (MLT) inhibited enzyme leakage and peroxidation in a concentration-dependent manner. It is concluded that DOX induces cardiotoxicity through lipid peroxidation and melatonin is an effective antioxidant against the reactive oxygen intermediates generated by DOX.
URI: http://hdl.handle.net/10397/8602
ISSN: 0024-3205
DOI: 10.1016/S0024-3205(00)00990-5
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