Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/8371
Title: Attenuation of fatty liver and prevention of hypercholesterolemia by extract of Curcuma longa through regulating the expression of CYP7A1, LDL-receptor, HO-1, and HMG-CoA reductase
Authors: Yiu, WF
Kwan, PL
Wong, CY
Kam, TS
Chiu, SM
Chan, SW
Chan, R
Keywords: Fatty liver
Hypercholesterolemia
LDL-cholesterol
Total cholesterol
Triglycerides
Turmeric
Issue Date: 2011
Publisher: Wiley-Blackwell
Source: Journal of food science, 2011, v. 76, no. 3, p. h80-h89 How to cite?
Journal: Journal of Food Science 
Abstract: The extract ofCurcuma longa, better known as turmeric, was orally administered to experimental rats that were fed a high-cholesterol diet to investigate whether it could regulate plasma lipids and cholesterol levels and possibly improve hepatic conditions. With turmeric supplements, rats showed a significant decrease in total plasma cholesterol and low-density lipoprotein cholesterol but an increase in high-density lipoprotein cholesterol when compared with rats that were fed a high-cholesterol diet alone. Fatty liver developed in hypercholesterolemic rats with the high-cholesterol diet treatment, and this condition was markedly improved when rats were provided with turmeric supplements at 100 mg/kg or 300 mg/kg of body mass. The turmeric treatment resulted in a significant decrease in the total amount of hepatic lipid. Histological staining of liver tissues with Sudan III and hematoxylin showed that rats fed with a high-cholesterol diet alone had more and larger granular fat bodies than rats having turmeric extract supplementation in their high-cholesterol diet. Reverse-transcription polymerase chain reaction was used to assess the expression levels of enzymes involved in fat metabolism and cellular homeostasis in experimental rat livers. The results showed that rats fed a high-cholesterol diet supplemented with turmeric extract had a significant increase in the expression of cholesterol 7 ?\-hydroxylase, hemeoxygenase 1, and low-density lipoprotein receptors but a significant decrease in 3-hydroxy-3-methyl-glutaryl-CoA reductase level when compared with rats fed a normal or high-cholesterol diet, showing that turmeric prevents hypercholesterolemia and the formation of fatty liver by the modulation of expressions of enzymes that are important to cholesterol metabolism.
URI: http://hdl.handle.net/10397/8371
ISSN: 0022-1147
DOI: 10.1111/j.1750-3841.2011.02042.x
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