Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/82289
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Applied Physics | - |
dc.creator | Xie, K | - |
dc.creator | Wang, N | - |
dc.creator | Lin, XD | - |
dc.creator | Wang, ZX | - |
dc.creator | Zhao, X | - |
dc.creator | Fang, PL | - |
dc.creator | Yue, HB | - |
dc.creator | Kim, JW | - |
dc.creator | Luo, J | - |
dc.creator | Cui, SY | - |
dc.creator | Yan, F | - |
dc.creator | Shi, P | - |
dc.date.accessioned | 2020-05-05T05:59:26Z | - |
dc.date.available | 2020-05-05T05:59:26Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/82289 | - |
dc.language.iso | en | en_US |
dc.publisher | eLife Sciences Publications | en_US |
dc.rights | © 2020, Xie et al. This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use and redistribution provided that the original author and source are credited. | en_US |
dc.rights | The following publication Xie, K., Wang, N., Lin, X. D., Wang, Z. X., Zhao, X., Fang, P. L., ... & Shi, P. (2020). Organic electrochemical transistor arrays for real-time mapping of evoked neurotransmitter release in vivo. Elife, 9, e50345, 1-19 is available at https://dx.doi.org/10.7554/eLife.50345 | en_US |
dc.title | Organic electrochemical transistor arrays for real-time mapping of evoked neurotransmitter release in vivo | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 1 | - |
dc.identifier.epage | 19 | - |
dc.identifier.volume | 9 | - |
dc.identifier.doi | 10.7554/eLife.50345 | - |
dcterms.abstract | Though neurotransmitters are essential elements in neuronal signal transduction, techniques for in vivo analysis are still limited. Here, we describe an organic electrochemical transistor array (OECT-array) technique for monitoring catecholamine neurotransmitters (CA-NTs) in rat brains. The OECT-array is an active sensor with intrinsic amplification capability, allowing real-time and direct readout of transient CA-NT release with a sensitivity of nanomolar range and a temporal resolution of several milliseconds. The device has a working voltage lower than half of that typically used in a prevalent cyclic voltammetry measurement, and operates continuously in vivo for hours without significant signal drift, which is inaccessible for existing methods. With the OECT-array, we demonstrate simultaneous mapping of evoked dopamine release at multiple striatal brain regions in different physiological scenarios, and reveal a complex cross-talk between the mesolimbic and the nigrostriatal pathways, which is heterogeneously affected by the reciprocal innervation between ventral tegmental area and substantia nigra pars compacta. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | eLife, 11 Feb. 2020, v. 9, e50345, p. 1-19 | - |
dcterms.isPartOf | eLife | - |
dcterms.issued | 2020 | - |
dc.identifier.isi | WOS:000521133000001 | - |
dc.identifier.scopus | 2-s2.0-85082147139 | - |
dc.identifier.pmid | 32043970 | - |
dc.identifier.eissn | 2050-084X | - |
dc.identifier.artn | e50345 | - |
dc.description.validate | 202006 bcrc | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | RGC-B1-168, OA_Scopus/WOS | en_US |
dc.description.fundingSource | RGC | en_US |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | Health and Medical Research Fund (06172336) from the Food and Health Bureau of Hong Kong SAR; the Science Technology and Innovation Committee of Shenzhen Municipality (JCYJ2017081810034239, JCYJ20180507181624871); National Natural Science Foundation of China (81871452) and City University of Hong Kong (7005084, 7005206). | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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Xie_Organic_Electrochemical_Transistor.pdf | 3.31 MB | Adobe PDF | View/Open |
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