Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/82266
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dc.contributorDepartment of Applied Biology and Chemical Technologyen_US
dc.contributorChinese Mainland Affairs Officeen_US
dc.creatorZhou, Len_US
dc.creatorPoon, CCWen_US
dc.creatorWong, KYen_US
dc.creatorCao, Sen_US
dc.creatorYu, Wen_US
dc.creatorDong, Xen_US
dc.creatorLee, WYWen_US
dc.creatorZhang, Yen_US
dc.creatorWong, MSen_US
dc.date.accessioned2020-05-05T05:59:20Z-
dc.date.available2020-05-05T05:59:20Z-
dc.identifier.urihttp://hdl.handle.net/10397/82266-
dc.language.isoenen_US
dc.publisherOxford published on behalf of Endocrine Societyen_US
dc.rights© Endocrine Society 2019.en_US
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.comen_US
dc.rightsThe following publication Liping Zhou, Christina Chui-Wa Poon, Ka-Ying Wong, Sisi Cao, Wenxuan Yu, Xiaoli Dong, Wayne Yuk-Wai Lee, Yan Zhang, Man-Sau Wong, Prenylflavonoid Icariin Induces Estrogen Response Element–Independent Estrogenic Responses in a Tissue-Selective Manner, Journal of the Endocrine Society, Volume 4, Issue 2, February 2020, bvz025 is available at https://dx.doi.org/10.1210/jendso/bvz025en_US
dc.subjectPhytoestrogensen_US
dc.subjectIcariinen_US
dc.subjectEstrogenic activityen_US
dc.subjectEstrogen receptoren_US
dc.subjectEstrogen deficiencyen_US
dc.subjectTissue-selectivityen_US
dc.titlePrenylflavonoid icariin induces estrogen response element-independent estrogenic responses in a tissue-selective manneren_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage1en_US
dc.identifier.epage17en_US
dc.identifier.volume4en_US
dc.identifier.issue2en_US
dc.identifier.doi10.1210/jendso/bvz025en_US
dcterms.abstractIcariin, a flavonoid phytoestrogen derived from Herba epimedii, has been reported to exert estrogenic effects in bone and activate phosphorylation of estrogen receptor (ER) a in osteoblastic cells. However, it is unclear whether icariin selectively exerts estrogenic activities in bone without inducing undesirable effects in other estrogen-sensitive tissues. The present study aimed to investigate the tissue-selective estrogenic activities of icariin in estrogen-sensitive tissues in vivo and in vitro. Longterm treatment with icariin effectively prevented bone of ovariectomized (OVX) rats from estrogen deficiency-induced osteoporotic changes in bone structure, bone mineral density, and trabecular properties. Moreover, icariin regulated the transcriptional events of estrogen-responsive genes related to bone remodeling and prevented dopaminergic neurons against OVX-induced changes by rescuing expression of estrogen-regulated tyrosine hydroxylase and dopamine transporter in the striatum. Unlike estrogen, icariin did not induce estrogenic effects in the uterus and breast in mature OVX rats or immature CD-1 mice. In vitro studies demonstrated that icariin exerted estrogen-like activities and regulated the expression of estrogen-responsive genes but did not induce estrogen response element- dependent luciferase activities in ER-positive cells. Our results support the hypothesis that icariin, through its distinct mechanism of actions in activating ER, selectively exerts estrogenic activities in different tissues and cell types.en_US
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationJournal of the Endocrine Society, Feb. 2020, v. 4, no. 2, bvz025, p. 1-17en_US
dcterms.isPartOfJournal of the Endocrine Societyen_US
dcterms.issued2020-02-
dc.identifier.isiWOS:000518167600017-
dc.identifier.scopus2-s2.0-85083053087-
dc.identifier.pmid32051921-
dc.identifier.eissn2472-1972en_US
dc.identifier.artnbvz025en_US
dc.description.validate202006 bcrcen_US
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumbera0691-n06, OA_Scopus/WOS, a2235-
dc.identifier.SubFormID948, 47168-
dc.description.fundingSourceRGCen_US
dc.description.fundingText15103614en_US
dc.description.fundingTextResearch Studentship support (RTKT) at the Hong Kong Polytechnic University; Essential Drug Research and Development (2019ZX09201004-003- 032) from the Ministry of Science and Technology of China Sanming Project of Medicine in Shenzhen (SZSM201808072); National Natural Science Foundation of China (81601110); Shenzhen Basic Research Program (JCYJ20170818111103886)en_US
dc.description.pubStatusPublisheden_US
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