Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/8223
Title: Liver fibrosis assessment using transient elastography guided with real-time b-mode ultrasound imaging : a feasibility study
Authors: Mak, TM
Huang, YP
Zheng, YP 
Keywords: Elasticity measurement
Indentation
Liver fibrosis
Soft tissue
Transient elastography
Ultrasound
Issue Date: 2013
Publisher: Elsevier
Source: Ultrasound in medicine and biology, 2013, v. 39, no. 6, p. 956-966 How to cite?
Journal: Ultrasound in medicine and biology 
Abstract: Liver fibrosis is a kind of chronic damage of the liver and can lead to cirrhosis, one of the top 10 causes of death in the Western world. However, there is still a lack of noninvasive methods for diagnosing liver fibrosis. Fibroscan (Echosens, Paris, France), a device based on A-mode transient elastography, has shown promising results. In this study, a transient elastography system with real-time B-mode imaging for non-invasive liver fibrosis assessment, named Liverscan, was developed; its performance was tested and compared with that of the Fibroscan. A specific measurement probe was designed and fabricated with a B-mode ultrasound transducer fixed along the axis of a mechanical vibrator. It was integrated with the Liverscan to measure liver stiffness based on the shear wave propagation in liver tissues. The system was validated by mechanical indentation test using custom-made agar-gelatin phantoms with different stiffness. To further test its feasibility, in vivo measurements were conducted in 67 volunteers (age, 34 ± 3 years; body mass index, 21.3 ± 2.8 kg/m2; Mean ± SD., 34 male and 33 female), including 20 patients with various liver diseases, and 28 (19 male and 9 female) being tested by both Liverscan and Fibroscan. A significant linear correlation between the stiffness measured by the mechanical indentation test and that by the Liverscan (r = 0.973; p < 0.001) was obtained. The in vivo liver stiffness measured by Liverscan was also correlated with that by Fibroscan significantly (r = 0.886; p < 0.001). There was a significant difference in liver stiffness between the 20 patients and the other healthy subjects (14.1 ± 3.4 kPa vs. 10.5 ± 2.1 kPa; p = 0.001). The intra- and inter-observer tests indicated that the measurements were repeatable with intra-class correlation coefficients being 0.987 (p < 0.001) and 0.988 (p < 0.001), respectively. This study demonstrated that Liverscan with a specifically designed probe was able to measure and differentiate liver of different stiffness using the established measurement protocol under the guidance of real-time B-mode ultrasound imaging.
URI: http://hdl.handle.net/10397/8223
ISSN: 0301-5629
EISSN: 1879-291X
DOI: 10.1016/j.ultrasmedbio.2013.01.009
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

5
Last Week
0
Last month
0
Citations as of Aug 17, 2017

WEB OF SCIENCETM
Citations

7
Last Week
0
Last month
0
Citations as of Jul 28, 2017

Page view(s)

37
Last Week
1
Last month
Checked on Aug 21, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.