Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/8218
Title: Current and future molecular diagnostics in colorectal cancer and colorectal adenoma
Authors: Tsang, AHF
Cheng, KH
Wong, ASP
Ng, SSM
Ma, BBY
Chan, CML
Tsui, NBY
Chan, LWC 
Yung, BYM 
Wong, SCC 
Keywords: Colorectal adenoma
Colorectal cancer
Fecal occult blood test
Molecular diagnostics
Noninvasive
Issue Date: 2014
Publisher: WJG Press
Source: World journal of gastroenterology, 2014, v. 20, no. 14, p. 3847-3857 How to cite?
Journal: World journal of gastroenterology 
Abstract: Colorectal cancer (CRC) is one of the most prevalent cancers in developed countries. On the other hand, CRC is also one of the most curable cancers if it is detected in early stages through regular colonoscopy or sigmoidoscopy. Since CRC develops slowly from precancerous lesions, early detection can reduce both the incidence and mortality of the disease. Fecal occult blood test is a widely used non-invasive screening tool for CRC. Although fecal occult blood test is simple and cost-effective in screening CRC, there is room for improvement in terms of the accuracy of the test. Genetic dysregulations have been found to play an important role in CRC development. With better understanding of the molecular basis of CRC, there is a growing expectation on the development of diagnostic tests based on more sensitive and specific molecular markers and those tests may provide a breakthrough to the limitations of current screening tests for CRC. In this review, the molecular basis of CRC development, the characteristics and applications of different non-invasive molecular biomarkers, as well as the technologies available for the detection were discussed. This review intended to provide a summary on the current and future molecular diagnostics in CRC and its pre-malignant state, colorectal adenoma.
URI: http://hdl.handle.net/10397/8218
ISSN: 1007-9327
EISSN: 2219-2840
DOI: 10.3748/wjg.v20.i14.3847
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