Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/81248
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dc.contributorChinese Mainland Affairs Office-
dc.contributorDepartment of Applied Biology and Chemical Technology-
dc.creatorChen, K-
dc.creatorDong, N-
dc.creatorChan, EWC-
dc.creatorChen, S-
dc.date.accessioned2019-08-23T08:29:54Z-
dc.date.available2019-08-23T08:29:54Z-
dc.identifier.urihttp://hdl.handle.net/10397/81248-
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.rights© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltden_US
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricteden_US
dc.subjectCiprofloxacin resistanceen_US
dc.subjectConjugative helper plasmiden_US
dc.subjectPlasmid integrationen_US
dc.subjectPMQR genesen_US
dc.titleTransmission of ciprofloxacin resistance in Salmonella mediated by a novel type of conjugative helper plasmidsen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage857en_US
dc.identifier.epage865en_US
dc.identifier.volume8en_US
dc.identifier.issue1en_US
dc.identifier.doi10.1080/22221751.2019.1626197en_US
dcterms.abstractCiprofloxacin resistance in Salmonella has been increasingly reported due to the emergence and dissemination of multiple Plasmid-Mediated Quinolone Resistance (PMQR) determinants, which are mainly located in non-conjugative plasmids or chromosome. In this study, we aimed to depict the molecular mechanisms underlying the rare phenomenon of horizontal transfer of ciprofloxacin resistance phenotype in Salmonella by conjugation experiments, S1-PFGE and complete plasmid sequencing. Two types of non-conjugative plasmids, namely an IncX1 type carrying a qnrS1 gene, and an IncH1 plasmid carrying the oqxAB-qnrS gene, both ciprofloxacin resistance determinants in Salmonella, were recovered from two Salmonella strains. Importantly, these non-conjugative plasmids could be fused with a novel Incl1 type conjugative helper plasmid, which could target insertion sequence (IS) elements located in the non-conjugative, ciprofloxacin-resistance-encoding plasmid through replicative transcription, eventually forming a hybrid conjugative plasmid transmissible among members of Enterobacteriaceae. Since our data showed that such conjugative helper plasmids are commonly detectable among clinical Salmonella strains, particularly S. Typhimurium, fusion events leading to generation and enhanced dissemination of conjugative ciprofloxacin resistance-encoding plasmids in Salmonella are expected to result in a sharp increase in the incidence of resistance to fluoroquinolone, the key choice for treating life-threatening Salmonella infections, thereby posing a serious public health threat.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationEmerging microbes & infections, 2019, v. 8, no. 1, p. 857-865-
dcterms.isPartOfEmerging microbes & infections-
dcterms.issued2019-
dc.identifier.isiWOS:000473826700003-
dc.identifier.scopus2-s2.0-85067451542-
dc.identifier.pmid31169081-
dc.identifier.eissn2222-1751en_US
dc.description.validate201908 bcma-
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_Scopus/WOSen_US
dc.description.pubStatusPublisheden_US
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