Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/8124
Title: Novel use of silymarin as delayed therapy for acetaminophen-induced acute hepatic injury
Authors: Hau, DKP
Wong, RSM
Cheng, GYM
Wong, WY
Tong, SW
Chan, KW
Leung, AKM
Zhu, GY
Lai, PBS
Lau, FY
Chui, CH
Gambari, R
Fong, DWF
Keywords: Acetaminophen
Hepatic injury
N-Acetyl cysteine
Silymarin
Issue Date: 2010
Publisher: Karger
Source: Forschende komplementarmedizin, 2010, v. 17, no. 4, p. 209-213 How to cite?
Journal: Forschende Komplementarmedizin 
Abstract: Aim: Recently, we have demonstrated that silymarin has a comparable pharmaceutical activity as Phyllanthus urinaria extract when used to rescue mice from acetaminophen-induced acute liver injury. In the present study, we further compared the therapeutic action of silymarin with N-acetyl cysteine (commonly used in clinical practice for emergency treatments) as a rescuer in mice after administering a lethal dose of acetaminophen for 24 h. Methods: Acute liver injury was induced in the treatment groups by intraperitoneally administered acetaminophen at a dose of 550 mg/kg body weight on day 1. The control group received an equal volume of physiological saline intraperitoneally. From day 2 to 4, the treatment groups received various doses of silymarin or N-acetyl cysteine orally once daily, while the control group and the acetaminophen group received an equal volume of water orally. The mortality rate was recorded in all groups. On day 5, all mice were sacrificed for examination. Results: Silymarin greatly improved the counteracting effects on mortality rate as compared to N-acetyl cysteine. Conclusion: Silymarin should be further considered as an antidote for patients with acetaminopheninduced acute hepatic injury and delayed treatment.
URI: http://hdl.handle.net/10397/8124
DOI: 10.1159/000319317
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