Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/80921
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Building and Real Estate | - |
dc.creator | Fang, Z | - |
dc.creator | Li, Y | - |
dc.creator | Zheng, Y | - |
dc.creator | Li, X | - |
dc.creator | Lu, YJ | - |
dc.creator | Yan, SC | - |
dc.creator | Wong, WL | - |
dc.creator | Chan, KF | - |
dc.creator | Wong, KY | - |
dc.creator | Sun, N | - |
dc.date.accessioned | 2019-06-27T06:36:33Z | - |
dc.date.available | 2019-06-27T06:36:33Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/80921 | - |
dc.language.iso | en | en_US |
dc.publisher | Royal Society of Chemistry | en_US |
dc.rights | This article is licensed under a Creative Commons Attribution - Non Commercial 3.0 Unported license. | en_US |
dc.rights | The following publication Fang, Z., Li, Y., Zheng, Y., Li, X., Lu, Y. J., Yan, S. C., ... & Sun, N. (2019). Antibacterial activity and mechanism of action of a thiophenyl substituted pyrimidine derivative. RSC advances, 9(19), 10739-10744 is available at https://doi.org/10.1039/C9RA01001G | en_US |
dc.title | Antibacterial activity and mechanism of action of a thiophenyl substituted pyrimidine derivative | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 10739 | en_US |
dc.identifier.epage | 10744 | en_US |
dc.identifier.volume | 9 | en_US |
dc.identifier.issue | 19 | en_US |
dc.identifier.doi | 10.1039/c9ra01001g | en_US |
dcterms.abstract | The issue of multidrug resistant bacteria is a worldwide health threat. To develop new antibacterial agents with new mechanisms of action is thus an urgent request to address this antibiotic resistance crisis. In the present study, a new thiophenyl-pyrimidine derivative was prepared and utilized as an effective antibacterial agent against Gram-positive strains. In the tests against MRSA and VREs, the compound showed higher antibacterial potency than that of vancomycin and methicillin. The mode of action is probably attributed to the effective inhibition of FtsZ polymerization, GTPase activity, and bacterial cell division, which cause bactericidal effects. The compound could be a potential candidate for further development as an effective antibiotic to combat drug-resistant bacteria. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | RSC advances, 2019, v. 9, no. 19, p. 10739-10744 | - |
dcterms.isPartOf | RSC advances | - |
dcterms.issued | 2019 | - |
dc.identifier.scopus | 2-s2.0-85064232597 | - |
dc.identifier.eissn | 2046-2069 | en_US |
dc.description.validate | 201906 bcma | en_US |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_IR/PIRA | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Fang_Antibacterial_activity_mechanism.pdf | 600.79 kB | Adobe PDF | View/Open |
Page views
127
Last Week
1
1
Last month
Citations as of Apr 21, 2024
Downloads
62
Citations as of Apr 21, 2024
SCOPUSTM
Citations
16
Citations as of Apr 19, 2024
WEB OF SCIENCETM
Citations
16
Citations as of Apr 25, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.