Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/80448
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Health Technology and Informatics | - |
dc.creator | Hou, JW | - |
dc.creator | Shi, JY | - |
dc.creator | Chen, L | - |
dc.creator | Lv, ZY | - |
dc.creator | Chen, X | - |
dc.creator | Cao, HH | - |
dc.creator | Xiang, Z | - |
dc.creator | Han, XD | - |
dc.date.accessioned | 2019-03-26T09:17:14Z | - |
dc.date.available | 2019-03-26T09:17:14Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/80448 | - |
dc.language.iso | en | en_US |
dc.publisher | BioMed Central | en_US |
dc.rights | © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | en_US |
dc.rights | The following publication Hou, J. W., Shi, J. Y., Chen, L., Lv, Z. Y., Chen, X., Cao, H. H., . . . Han, X. D. (2018). M2 macrophages promote myofibroblast differentiation of LR-MSCs and are associated with pulmonary fibrogenesis. Cell Communication and Signaling, 16, 89, 1-14 is available at https://dx.doi.org/10.1186/s12964-018-0300-8 | en_US |
dc.subject | Idiopathic pulmonary fibrosis (IPF) | en_US |
dc.subject | M2 macrophages | en_US |
dc.subject | Lung resident mesenchymal stem cells (LR-MSCs) | en_US |
dc.subject | Myofibroblast differentiation | en_US |
dc.title | M2 macrophages promote myofibroblast differentiation of LR-MSCs and are associated with pulmonary fibrogenesis | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 1 | - |
dc.identifier.epage | 14 | - |
dc.identifier.volume | 16 | - |
dc.identifier.doi | 10.1186/s12964-018-0300-8 | - |
dcterms.abstract | Background: Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by the histopathological pattern of usual interstitial pneumonia and is associated with a high mortality rate. Recently, lung resident mesenchymal stem cells (LR-MSCs) have been identified as an important contributor to myofibroblast activation in pulmonary fibrosis. Macrophages are also believed to play a critical role in pulmonary fibrosis. However, the underlying connections between LR-MSCs and macrophages in the pathogenesis of pulmonary fibrosis are still elusive. | - |
dcterms.abstract | Methods: In this study, we investigated the interaction between LR-MSCs and macrophages using a bleomycin-induced mouse pulmonary fibrosis model and a coculture system. | - |
dcterms.abstract | Results: Here, we show that blocking pulmonary macrophage infiltration attenuated bleomycin-induced pulmonary fibrosis. In addition, as determined by flow cytometry, we discovered that the recruited macrophages in fibrotic lungs of bleomycin-treated mice were mainly M2 macrophages. In particular, we found that M2, rather than M1 macrophages, promoted myofibroblast differentiation of LR-MSCs. Moreover, we demonstrated that suppression of the Wnt/-catenin signaling pathway could attenuate myofibroblast differentiation of LR-MSCs induced by M2 macrophages and bleomycin-induced pulmonary fibrosis. Tissue samples from IPF patients confirmed the infiltration of M2 macrophages and activation of Wnt/-catenin signaling pathway. | - |
dcterms.abstract | Conclusion: In summary, this study furthered our understanding of the pulmonary fibrosis pathogenesis and highlighted M2 macrophages as a critical target for treating pulmonary fibrosis. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Cell communication and signaling, 23 Nov. 2018, v. 16, 89, p. 1-14 | - |
dcterms.isPartOf | Cell communication and signaling | - |
dcterms.issued | 2018 | - |
dc.identifier.isi | WOS:000451017900001 | - |
dc.identifier.scopus | 2-s2.0-85057090237 | - |
dc.identifier.pmid | 30470231 | - |
dc.identifier.eissn | 1478-811X | - |
dc.identifier.artn | 89 | - |
dc.description.validate | 201903 bcrc | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_IR/PIRA | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
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File | Description | Size | Format | |
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Hou_M2_Promote_Differentiation.pdf | 9.63 MB | Adobe PDF | View/Open |
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