Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/80448
PIRA download icon_1.1View/Download Full Text
DC FieldValueLanguage
dc.contributorDepartment of Health Technology and Informatics-
dc.creatorHou, JW-
dc.creatorShi, JY-
dc.creatorChen, L-
dc.creatorLv, ZY-
dc.creatorChen, X-
dc.creatorCao, HH-
dc.creatorXiang, Z-
dc.creatorHan, XD-
dc.date.accessioned2019-03-26T09:17:14Z-
dc.date.available2019-03-26T09:17:14Z-
dc.identifier.urihttp://hdl.handle.net/10397/80448-
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.rights© The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en_US
dc.rightsThe following publication Hou, J. W., Shi, J. Y., Chen, L., Lv, Z. Y., Chen, X., Cao, H. H., . . . Han, X. D. (2018). M2 macrophages promote myofibroblast differentiation of LR-MSCs and are associated with pulmonary fibrogenesis. Cell Communication and Signaling, 16, 89, 1-14 is available at https://dx.doi.org/10.1186/s12964-018-0300-8en_US
dc.subjectIdiopathic pulmonary fibrosis (IPF)en_US
dc.subjectM2 macrophagesen_US
dc.subjectLung resident mesenchymal stem cells (LR-MSCs)en_US
dc.subjectMyofibroblast differentiationen_US
dc.titleM2 macrophages promote myofibroblast differentiation of LR-MSCs and are associated with pulmonary fibrogenesisen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage1-
dc.identifier.epage14-
dc.identifier.volume16-
dc.identifier.doi10.1186/s12964-018-0300-8-
dcterms.abstractBackground: Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by the histopathological pattern of usual interstitial pneumonia and is associated with a high mortality rate. Recently, lung resident mesenchymal stem cells (LR-MSCs) have been identified as an important contributor to myofibroblast activation in pulmonary fibrosis. Macrophages are also believed to play a critical role in pulmonary fibrosis. However, the underlying connections between LR-MSCs and macrophages in the pathogenesis of pulmonary fibrosis are still elusive.-
dcterms.abstractMethods: In this study, we investigated the interaction between LR-MSCs and macrophages using a bleomycin-induced mouse pulmonary fibrosis model and a coculture system.-
dcterms.abstractResults: Here, we show that blocking pulmonary macrophage infiltration attenuated bleomycin-induced pulmonary fibrosis. In addition, as determined by flow cytometry, we discovered that the recruited macrophages in fibrotic lungs of bleomycin-treated mice were mainly M2 macrophages. In particular, we found that M2, rather than M1 macrophages, promoted myofibroblast differentiation of LR-MSCs. Moreover, we demonstrated that suppression of the Wnt/-catenin signaling pathway could attenuate myofibroblast differentiation of LR-MSCs induced by M2 macrophages and bleomycin-induced pulmonary fibrosis. Tissue samples from IPF patients confirmed the infiltration of M2 macrophages and activation of Wnt/-catenin signaling pathway.-
dcterms.abstractConclusion: In summary, this study furthered our understanding of the pulmonary fibrosis pathogenesis and highlighted M2 macrophages as a critical target for treating pulmonary fibrosis.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationCell communication and signaling, 23 Nov. 2018, v. 16, 89, p. 1-14-
dcterms.isPartOfCell communication and signaling-
dcterms.issued2018-
dc.identifier.isiWOS:000451017900001-
dc.identifier.scopus2-s2.0-85057090237-
dc.identifier.pmid30470231-
dc.identifier.eissn1478-811X-
dc.identifier.artn89-
dc.description.validate201903 bcrc-
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_IR/PIRAen_US
dc.description.pubStatusPublisheden_US
Appears in Collections:Journal/Magazine Article
Files in This Item:
File Description SizeFormat 
Hou_M2_Promote_Differentiation.pdf9.63 MBAdobe PDFView/Open
Open Access Information
Status open access
File Version Version of Record
Access
View full-text via PolyU eLinks SFX Query
Show simple item record

Page views

97
Last Week
2
Last month
Citations as of Mar 24, 2024

Downloads

109
Citations as of Mar 24, 2024

SCOPUSTM   
Citations

119
Citations as of Mar 28, 2024

WEB OF SCIENCETM
Citations

112
Citations as of Mar 28, 2024

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.