Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/8028
Title: Central administration of Neuropeptide FF and related peptides attenuate systemic morphine analgesia in mice
Authors: Fang, Q
Jiang, TN
Li, N
Han, ZL
Wang, R
Keywords: Analgesia
Intraperitoneal (i.p.) injection
Mice
Morphine
Neuropeptide FF (NPFF)
Receptor
Issue Date: 2011
Publisher: Bentham Science Publishers
Source: Protein and peptide letters, 2011, v. 18, no. 4, p. 403-409 How to cite?
Journal: Protein and peptide letters 
Abstract: Neuropeptide FF (NPFF) belongs to an opioid-modulating peptide family. NPFF has been reported to play important roles in the control of pain and analgesia through interactions with the opioid system. However, very few studies examined the effect of supraspinal NPFF system on analgesia induced by opiates administered at the peripheral level. In the present study, intracerebroventricular (i.c.v.) injection of NPFF (1, 3 and 10 nmol) dose-dependently inhibited systemic morphine (0.12 mg, i.p.) analgesia in the mouse tail flick test. Similarly, i.c.v. administration of dNPA and NPVF, two agonists highly selective for NPFF2 and NPFF1 receptors, respectively, decreased analgesia induced by i.p. morphine in mice. Furthermore, these anti-opioid activities of NPFF and related peptides were blocked by pretreatment with the NPFF receptors selective antagonist RF9 (10 nmol, i.c.v.). These results demonstrate that activation of central NPFF1 and NPFF2 receptors has the similar anti-opioid actions on the antinociceptive effect of systemic morphine.
URI: http://hdl.handle.net/10397/8028
ISSN: 0929-8665
EISSN: 1875-5305
DOI: 10.2174/092986611794654012
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

16
Last Week
0
Last month
0
Citations as of Aug 20, 2017

WEB OF SCIENCETM
Citations

15
Last Week
0
Last month
0
Citations as of Aug 20, 2017

Page view(s)

42
Last Week
3
Last month
Checked on Aug 20, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.