Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/80025
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dc.contributorDepartment of Health Technology and Informatics-
dc.creatorZaki, H-
dc.creatorGasmelseed, N-
dc.creatorAbdalla, B-
dc.creatorYip, SP-
dc.date.accessioned2018-12-21T07:14:41Z-
dc.date.available2018-12-21T07:14:41Z-
dc.identifier.issn1110-8630-
dc.identifier.urihttp://hdl.handle.net/10397/80025-
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rights© 2018 Ain Shams University. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/)en_US
dc.rightsThe following publication Zaki, H., Gasmelseed, N., Abdalla, B., & Yip, S. P. (2018). Association of toll-like receptor 2 polymorphisms with susceptibility to pulmonary tuberculosis in Sudanese. Egyptian Journal of Medical Human Genetics, 19, 261-265 is available at https://dx.doi.org/10.1016/j.ejmhg.2018.01.001en_US
dc.subjectPolymorphismsen_US
dc.subjectPulmonary tuberculosisen_US
dc.subjectToll-like receptor 2en_US
dc.titleAssociation of toll-like receptor 2 polymorphisms with susceptibility to pulmonary tuberculosis in Sudaneseen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage261-
dc.identifier.epage265-
dc.identifier.volume19-
dc.identifier.issue3-
dc.identifier.doi10.1016/j.ejmhg.2018.01.001-
dcterms.abstractBackground: Mycobacterium tuberculosis (MT) is a leading cause of death worldwide, and the incidence of the tuberculosis) has been escalating due to the convergence of multidrug-resistant strains and HIV infection epidemics. Genetic and nongenetic factors of both the bacterium and the host have impact on the host response to MT. Toll-like receptors (TLRs) play an important role in the innate immune response to pathogens. It has been proved that viable Mycobacterium bacilli contain distinct ligands that activate cells via TLR2.-
dcterms.abstractAim: This study was conducted to test the association of TLR2 gene polymorphisms with susceptibility to pulmonary tuberculosis in Sudanese.-
dcterms.abstractSubjects and methods: A case-control study of 207 Sudanese patients with pulmonary tuberculosis and 395 healthy controls was used. Three tag single nucleotide polymorphisms (SNPs) in TLR2 gene and its 3-Kb flanking regions on chromosome 4 were selected. The tag approach was set to r2 > 0.8 and minor allele frequency (MAF) > 0.2. Genotyping was performed by polymerase chain reaction followed by restriction fragment length polymorphism method.-
dcterms.abstractResults: Genotypes of the 3 SNPs (rs1816702, rs3804099, and rs7656411) were estimated and compared. The stepwise regression procedure demonstrated that elimination of rs1816702 and rs3804099 from the model did not have any significant effect (p =.0685,.7300 respectively), while rs7656411 was significantly associated with tuberculosis susceptibility (p =.0372). TLR2 rs7656411 TG and GG genotypes frequencies were higher in pulmonary tuberculosis patients (OR = 1.74, 95% CI = 1.09–2.78, and OR = 2.24, 95% CI = 1.37–3.68 respectively). The haplotype TCG of TLR2 SNPs was also associated with TB susceptibility (p =.0004).-
dcterms.abstractConclusion: Our study suggests that allele G of rs765641 on TLR2 gene might influence susceptibility to pulmonary tuberculosis in Sudanese.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationEgyptian journal of medical human genetics, 2018, v. 19, no. 3, p. 261-265-
dcterms.isPartOfEgyptian journal of medical human genetics-
dcterms.issued2018-
dc.identifier.scopus2-s2.0-85040584391-
dc.identifier.eissn2090-2441-
dc.identifier.rosgroupid2017003359-
dc.description.ros2017-2018 > Academic research: refereed > Publication in refereed journal-
dc.description.validate201812 bcrc-
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_IR/PIRAen_US
dc.description.pubStatusPublisheden_US
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