Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/80025
DC Field | Value | Language |
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dc.contributor | Department of Health Technology and Informatics | - |
dc.creator | Zaki, H | - |
dc.creator | Gasmelseed, N | - |
dc.creator | Abdalla, B | - |
dc.creator | Yip, SP | - |
dc.date.accessioned | 2018-12-21T07:14:41Z | - |
dc.date.available | 2018-12-21T07:14:41Z | - |
dc.identifier.issn | 1110-8630 | - |
dc.identifier.uri | http://hdl.handle.net/10397/80025 | - |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | © 2018 Ain Shams University. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/) | en_US |
dc.rights | The following publication Zaki, H., Gasmelseed, N., Abdalla, B., & Yip, S. P. (2018). Association of toll-like receptor 2 polymorphisms with susceptibility to pulmonary tuberculosis in Sudanese. Egyptian Journal of Medical Human Genetics, 19, 261-265 is available at https://dx.doi.org/10.1016/j.ejmhg.2018.01.001 | en_US |
dc.subject | Polymorphisms | en_US |
dc.subject | Pulmonary tuberculosis | en_US |
dc.subject | Toll-like receptor 2 | en_US |
dc.title | Association of toll-like receptor 2 polymorphisms with susceptibility to pulmonary tuberculosis in Sudanese | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 261 | - |
dc.identifier.epage | 265 | - |
dc.identifier.volume | 19 | - |
dc.identifier.issue | 3 | - |
dc.identifier.doi | 10.1016/j.ejmhg.2018.01.001 | - |
dcterms.abstract | Background: Mycobacterium tuberculosis (MT) is a leading cause of death worldwide, and the incidence of the tuberculosis) has been escalating due to the convergence of multidrug-resistant strains and HIV infection epidemics. Genetic and nongenetic factors of both the bacterium and the host have impact on the host response to MT. Toll-like receptors (TLRs) play an important role in the innate immune response to pathogens. It has been proved that viable Mycobacterium bacilli contain distinct ligands that activate cells via TLR2. | - |
dcterms.abstract | Aim: This study was conducted to test the association of TLR2 gene polymorphisms with susceptibility to pulmonary tuberculosis in Sudanese. | - |
dcterms.abstract | Subjects and methods: A case-control study of 207 Sudanese patients with pulmonary tuberculosis and 395 healthy controls was used. Three tag single nucleotide polymorphisms (SNPs) in TLR2 gene and its 3-Kb flanking regions on chromosome 4 were selected. The tag approach was set to r2 > 0.8 and minor allele frequency (MAF) > 0.2. Genotyping was performed by polymerase chain reaction followed by restriction fragment length polymorphism method. | - |
dcterms.abstract | Results: Genotypes of the 3 SNPs (rs1816702, rs3804099, and rs7656411) were estimated and compared. The stepwise regression procedure demonstrated that elimination of rs1816702 and rs3804099 from the model did not have any significant effect (p =.0685,.7300 respectively), while rs7656411 was significantly associated with tuberculosis susceptibility (p =.0372). TLR2 rs7656411 TG and GG genotypes frequencies were higher in pulmonary tuberculosis patients (OR = 1.74, 95% CI = 1.09–2.78, and OR = 2.24, 95% CI = 1.37–3.68 respectively). The haplotype TCG of TLR2 SNPs was also associated with TB susceptibility (p =.0004). | - |
dcterms.abstract | Conclusion: Our study suggests that allele G of rs765641 on TLR2 gene might influence susceptibility to pulmonary tuberculosis in Sudanese. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Egyptian journal of medical human genetics, 2018, v. 19, no. 3, p. 261-265 | - |
dcterms.isPartOf | Egyptian journal of medical human genetics | - |
dcterms.issued | 2018 | - |
dc.identifier.scopus | 2-s2.0-85040584391 | - |
dc.identifier.eissn | 2090-2441 | - |
dc.identifier.rosgroupid | 2017003359 | - |
dc.description.ros | 2017-2018 > Academic research: refereed > Publication in refereed journal | - |
dc.description.validate | 201812 bcrc | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_IR/PIRA | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
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Zaki_Toll-like_Receptor_2.pdf | 287.54 kB | Adobe PDF | View/Open |
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