Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/80011
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dc.contributorInstitute of Textiles and Clothing-
dc.contributorSchool of Nursing-
dc.contributorDepartment of Rehabilitation Sciences-
dc.creatorSupriya R-
dc.creatorTam BT-
dc.creatorYu, AP-
dc.creatorLee PH-
dc.creatorLai CW-
dc.creatorCheng KK-
dc.creatorYau SY-
dc.creatorChan LW-
dc.creatorYung BY-
dc.creatorSheridan, S-
dc.creatorSiu, PM-
dc.date.accessioned2018-12-21T07:14:38Z-
dc.date.available2018-12-21T07:14:38Z-
dc.identifier.urihttp://hdl.handle.net/10397/80011-
dc.language.isoenen_US
dc.publisherPublic Library of Scienceen_US
dc.rightsCopyright: © 2018 Supriya et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.rightsThe following publication Supriya, R., Tam, B. T., Yu, A. P., Lee, P. H., Lai, C. W., Cheng, K. K., . . . Siu, P. M. (2018). Adipokines demonstrate the interacting influence of central obesity with other cardiometabolic risk factors of metabolic syndrome in Hong Kong Chinese adults. PLoS ONE, 13(8), e0201585, 1-20 is available at https://dx.doi.org/10.1371/journal.pone.0201585en_US
dc.titleAdipokines demonstrate the interacting influence of central obesity with other cardiometabolic risk factors of metabolic syndrome in Hong Kong Chinese adultsen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage1en_US
dc.identifier.epage20en_US
dc.identifier.volume13en_US
dc.identifier.issue8en_US
dc.identifier.doi10.1371/journal.pone.0201585en_US
dcterms.abstractObjective Metabolic syndrome (MetS) or prediabetes is a complex disorder that is defined by a clustering of cardiometabolic risk factors, including obesity, hypertriglyceridemia, reduced high-density lipoprotein (HDL) cholesterol, hypertension, and insulin resistance. Among cardiometabolic risk factors, central obesity plays a key role in the development of MetS through alterations in the secretion of adipokines and interacts with other MetS risk factors to unfavorably influence overall cardiometabolic risk. Obesity has grasped epidemic proportions in Asia, which has the highest number of people with diabetes in the world. But, the importance of central obesity in the clustering of all four MetS risk factors or vice versa in predicting severity of MetS has not yet been investigated in Asian population. Therefore, the present study examined the influence of central obesity on circulating levels of adipokines through its interaction with the clustering of cardiometabolic risk factors of MetS including hyperglycemia, hypertriglyceridemia, dyslipidemia and hypertension in Hong Kong Chinese adults.-
dcterms.abstractSubjects Blood samples from 83 Hong Kong Chinese adults, who were previously screened for MetS according to the guideline of the United States National Cholesterol Education Program Expert Panel Adult Treatment Panel III criteria were selected. Insulin and adipokines, including visfatin, chemerin, plasminogen activator inhibitor-1 (PAI-1), resistin, C-C motif chemokine ligand 2 (CCL-2), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), tumour necrosis factor-α (TNF-α), leptin and adiponectin were assessed.-
dcterms.abstractResults The interacting effect of central obesity with all of the other four MetS risk factors increased the proinflammatory status of adipokines (TNF-α, leptin) and decreased the anti-inflammatory status of adipokine (adiponectin).-
dcterms.abstractConclusion Our results indicate that the inflammatory status of MetS may be more severe in the presence of central obesity. Adipokines, as biomarkers for pathophysiological changes, may help to improve early patient identification and to predict MetS-associated morbidity and mortality.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationPLoS one, 2018, v. 13, no. 8, e0201585, p. 1-20-
dcterms.isPartOfPLoS one-
dcterms.issued2018-
dc.identifier.scopus2-s2.0-85053491700-
dc.identifier.eissn1932-6203en_US
dc.identifier.artne0201585en_US
dc.description.validate201812 bcrc-
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumbera0763-n20en_US
dc.identifier.SubFormID1513en_US
dc.description.fundingSourceSelf-fundeden_US
dc.description.pubStatusPublisheden_US
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