Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/80011
DC Field | Value | Language |
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dc.contributor | Institute of Textiles and Clothing | - |
dc.contributor | School of Nursing | - |
dc.contributor | Department of Rehabilitation Sciences | - |
dc.creator | Supriya R | - |
dc.creator | Tam BT | - |
dc.creator | Yu, AP | - |
dc.creator | Lee PH | - |
dc.creator | Lai CW | - |
dc.creator | Cheng KK | - |
dc.creator | Yau SY | - |
dc.creator | Chan LW | - |
dc.creator | Yung BY | - |
dc.creator | Sheridan, S | - |
dc.creator | Siu, PM | - |
dc.date.accessioned | 2018-12-21T07:14:38Z | - |
dc.date.available | 2018-12-21T07:14:38Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/80011 | - |
dc.language.iso | en | en_US |
dc.publisher | Public Library of Science | en_US |
dc.rights | Copyright: © 2018 Supriya et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | en_US |
dc.rights | The following publication Supriya, R., Tam, B. T., Yu, A. P., Lee, P. H., Lai, C. W., Cheng, K. K., . . . Siu, P. M. (2018). Adipokines demonstrate the interacting influence of central obesity with other cardiometabolic risk factors of metabolic syndrome in Hong Kong Chinese adults. PLoS ONE, 13(8), e0201585, 1-20 is available at https://dx.doi.org/10.1371/journal.pone.0201585 | en_US |
dc.title | Adipokines demonstrate the interacting influence of central obesity with other cardiometabolic risk factors of metabolic syndrome in Hong Kong Chinese adults | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 1 | en_US |
dc.identifier.epage | 20 | en_US |
dc.identifier.volume | 13 | en_US |
dc.identifier.issue | 8 | en_US |
dc.identifier.doi | 10.1371/journal.pone.0201585 | en_US |
dcterms.abstract | Objective Metabolic syndrome (MetS) or prediabetes is a complex disorder that is defined by a clustering of cardiometabolic risk factors, including obesity, hypertriglyceridemia, reduced high-density lipoprotein (HDL) cholesterol, hypertension, and insulin resistance. Among cardiometabolic risk factors, central obesity plays a key role in the development of MetS through alterations in the secretion of adipokines and interacts with other MetS risk factors to unfavorably influence overall cardiometabolic risk. Obesity has grasped epidemic proportions in Asia, which has the highest number of people with diabetes in the world. But, the importance of central obesity in the clustering of all four MetS risk factors or vice versa in predicting severity of MetS has not yet been investigated in Asian population. Therefore, the present study examined the influence of central obesity on circulating levels of adipokines through its interaction with the clustering of cardiometabolic risk factors of MetS including hyperglycemia, hypertriglyceridemia, dyslipidemia and hypertension in Hong Kong Chinese adults. | - |
dcterms.abstract | Subjects Blood samples from 83 Hong Kong Chinese adults, who were previously screened for MetS according to the guideline of the United States National Cholesterol Education Program Expert Panel Adult Treatment Panel III criteria were selected. Insulin and adipokines, including visfatin, chemerin, plasminogen activator inhibitor-1 (PAI-1), resistin, C-C motif chemokine ligand 2 (CCL-2), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), tumour necrosis factor-α (TNF-α), leptin and adiponectin were assessed. | - |
dcterms.abstract | Results The interacting effect of central obesity with all of the other four MetS risk factors increased the proinflammatory status of adipokines (TNF-α, leptin) and decreased the anti-inflammatory status of adipokine (adiponectin). | - |
dcterms.abstract | Conclusion Our results indicate that the inflammatory status of MetS may be more severe in the presence of central obesity. Adipokines, as biomarkers for pathophysiological changes, may help to improve early patient identification and to predict MetS-associated morbidity and mortality. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | PLoS one, 2018, v. 13, no. 8, e0201585, p. 1-20 | - |
dcterms.isPartOf | PLoS one | - |
dcterms.issued | 2018 | - |
dc.identifier.scopus | 2-s2.0-85053491700 | - |
dc.identifier.eissn | 1932-6203 | en_US |
dc.identifier.artn | e0201585 | en_US |
dc.description.validate | 201812 bcrc | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | a0763-n20 | en_US |
dc.identifier.SubFormID | 1513 | en_US |
dc.description.fundingSource | Self-funded | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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Supriya_Adipokines_Obesity_Cardiometabolic.pdf | 1.47 MB | Adobe PDF | View/Open |
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