Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/79982
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dc.contributorDepartment of Applied Biology and Chemical Technology-
dc.contributorChinese Mainland Affairs Office-
dc.creatorDong, N-
dc.creatorYang X-
dc.creatorZhang, R-
dc.creatorChan, EWC-
dc.creatorChen, S-
dc.date.accessioned2018-12-21T07:14:31Z-
dc.date.available2018-12-21T07:14:31Z-
dc.identifier.urihttp://hdl.handle.net/10397/79982-
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.rights© The Author(s) 2018en_US
dc.rightsOpen Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any mediumor format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changesweremade. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en_US
dc.rightsThe following publication Dong, N., Yang, X., Zhang, R., Chan, E. W. -., & Chen, S. (2018). Tracking microevolution events among ST11 carbapenemase-producing hypervirulent klebsiella pneumoniae outbreak strains. Emerging Microbes and Infections, 7, 146, 1-8 is available at https://dx.doi.org/10.1038/s41426-018-0146-6en_US
dc.titleTracking microevolution events among ST11 carbapenemase-producing hypervirulent Klebsiella pneumoniae outbreak strainsen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage1en_US
dc.identifier.epage8en_US
dc.identifier.volume7en_US
dc.identifier.issue1en_US
dc.identifier.doi10.1038/s41426-018-0146-6en_US
dcterms.abstractThe recent convergence of genetic elements encoding phenotypic carbapenem-resistance and hypervirulence within a single Klebsiella pneumoniae host strain represents a major public concern. To obtain a better understanding of the genetic characteristic of this emerging ‘superbug’, the complete genomes of 3 isolates of ST11 carbapenemase-producing hypervirulent K. pneumoniae were generated using the Oxford nanopore MinION platform. Comparative whole-genome analysis identified 13 SNPs and 3 major regions of indels in the chromosomes of the clonally disseminated isolates. ISKpn18-mediated disruption in the mgrB gene, which was associated with colistin resistance, was identified in two later strains, leading to the emergence of hypervirulent K. pneumoniae that was simultaneously colistin- and carbapenem-resistant. Five plasmids were recovered from each isolate, including a 178 Kb IncHI1B/FIB-type rmpA2-bearing virulence plasmid, a 177.5 Kb IncFII/R self-transferable blaKPC-2-bearing MDR plasmid, a 99.7 Kb Incl1 plasmid and two ColRNAI-type plasmids of sizes of 11.9 and 5.6 Kb, respectively. The presence of homologous regions between the non-conjugative virulence plasmid and conjugative blaKPC-2-bearing MDR plasmid suggests that transmission of the virulence plasmid from ST23 K. pneumoniae to ST11 CRKP may be mediated by the co-integrated transfer of these two plasmids. Emergence of colistin-resistant and carbapenemase-producing hypervirulent K. pneumoniae strains further emphasizes the urgency for the establishment of a coordinated global program to eradicate hypervirulent and/or pan-drug-resistant strains of K. pneumoniae from clinical settings and the community.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationEmerging microbes & infections, 2018, v. 7, no. 1, 146, p. 1-8-
dcterms.isPartOfEmerging microbes & infections-
dcterms.issued2018-
dc.identifier.scopus2-s2.0-85051472842-
dc.identifier.eissn2222-1751en_US
dc.identifier.artn146en_US
dc.description.validate201812 bcrcen_US
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_IR/PIRAen_US
dc.description.pubStatusPublisheden_US
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