Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/79847
Title: A sensing platform for hypoxanthine detection based on amino-functionalized metal organic framework nanosheet with peroxidase mimic and fluorescence properties
Authors: Hu, SS
Yan, JJ
Huang, XM
Guo, LH
Lin, ZY
Luo, F
Qiu, B
Wong, KY 
Chen, GN
Keywords: Bottom-up synthesis
Two-dimensional metal organic framework
Nanosheet
Biosensor
Peroxidase mimic
Hypoxanthine
Issue Date: 2018
Publisher: Elsevier
Source: Sensors and actuators. B, Chemical, 15 Aug. 2018, v. 267, p. 312-319 How to cite?
Journal: Sensors and actuators. B, Chemical 
Abstract: The amino-functionalized metal organic framework (NH2-Cu-MOF) was fabricated via bottom-up synthesis strategy. Detailed characterization using electron microscopy, X-ray photoelectron spectroscopy and atomic force microscopy demonstrated that the as-synthesized NH2-Cu-MOF was two-dimensional nanosheet (a thin thickness similar to 4.2 nm). Results showed that the as-synthesized NH2-Cu-MOF nanosheet possessed fluorescence property (lambda(em) = 425 nm) as well as peroxidase mimic activity. On the basis of these two properties, we proposed a biosensor for hypoxanthine detection. The fluorescence intensity had a linear relationship with the hypoxanthine concentration in the range of 10-2000 mu M. The limit of detection was 3.93 mu M (S/N = 3). This work contributes to the synthesis of a new two-dimensional MOF nanosheet and extends the application of two-dimensional MOF nanosheet on biological luminescent sensors.
URI: http://hdl.handle.net/10397/79847
ISSN: 0925-4005
EISSN: 1873-3077
DOI: 10.1016/j.snb.2018.04.055
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