Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/79826
Title: A smart europium-ruthenium complex as anticancer prodrug : controllable drug release and real-time monitoring under different light excitations
Authors: Li, HG
Xie, C
Lan, RF
Zha, S
Chan, CF
Wong, WY 
Ho, KL
Chan, BD 
Luo, YX
Zhang, JX
Law, GL 
Tai, WCS 
Bünzli, JCG
Wong, KL
Issue Date: 2017
Publisher: American Chemical Society
Source: Journal of medicinal chemistry, 9 Nov. 2017, v. 60, no. 21, p. 8923-8932 How to cite?
Journal: Journal of medicinal chemistry 
Abstract: A unique, dual-function, photoactivatable anticancer prodrug, RuEuL, has been tailored that features a ruthenium(II) complex linked to a cyclen-europium chelate via a pi-conjugated bridge. Under irradiation at 488 nm, the dark-inactive prodrug undergoes photodissociation, releasing the DNA-damaging ruthenium species. Under evaluation window irradiation (lambda(irr) = one-photon 350 nm or two-photon 700 nm), the drug delivery process can be quantitatively monitored in real-time because of the long-lived red europium: emission. Linear relationships between released drug concentration and ESI-MS or luminescence responses are established. Finally, the efficiency of the new prodrug is demonstrated both in vitro RuEuL anticancer prodrug over some existing ones and open the way for decisive improvements in multipurpose prodrugs.
URI: http://hdl.handle.net/10397/79826
ISSN: 0022-2623
EISSN: 1520-4804
DOI: 10.1021/acs.jmedchem.7b01162
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