Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/7940
Title: Comparison between phytoestrogens and estradiol in the preventionof atheroma in ovariectomized cholesterol-fed rabbits
Authors: Haines, C
James, A
Sahota, D
Chen, ZY
Panesar, N
Tomlinson, B
Chow, L
Benzie, I 
Husband, A
Keywords: Atherosclerosis
Estradiol
Phytoestrogen
Issue Date: 2006
Publisher: Taylor & Francis
Source: Climacteric, 2006, v. 9, no. 6, p. 430-436 How to cite?
Journal: Climacteric 
Abstract: Objectives: There is increasing interest in the role of complementary and alternative medicines for the treatment of menopause-related problems. This study compared the preventive effect on atheroma formation of a commercially available mixed phytoestrogen concentrate with that of estradiol. Methods: An ovariectomized cholesterol-fed rabbit model of atheroma formation was used. Rabbits were ovariectomized before the commencement of the 12-week treatment period. There were two control groups. Control Group 1 received isoflavone-free rabbit chow whilst Control Group 2 received 1% cholesterol-enriched isoflavone-free rabbit chow. Rabbits in Group 3 received 1% cholesterol-enriched isoflavone-free rabbit chow plus a 500 mg tablet containing a concentrated extract of Trifolium pretense (red clover). Rabbits in Group 4 received 1% cholesterol-enriched isoflavone-free rabbit chow plus a 0.5 mg tablet of oral estradiol. Atheroma formation was measured by, first, calculation of the area of atheroma on the intimal surface, and, second, measuring the cholesterol content in the aorta. Results: There were no significant differences in serum cholesterol between the cholesterol-fed control Group 2 and the treatment Groups 3 and 4. However, there was significantly less staining for atheroma and significantly less cholesterol accumulation in the aorta in Group 4 (estradiol-treated) rabbits compared with either control Group 2 or Group 3 (phytoestrogen-treated) rabbits. Conclusion: In this study, only estradiol was shown to have a significant protective effect against atheroma formation.
URI: http://hdl.handle.net/10397/7940
ISSN: 1369-7137
EISSN: 1473-0804
DOI: 10.1080/13697130600863266
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