Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/79256
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dc.contributorDepartment of Applied Biology and Chemical Technology-
dc.creatorAndresen, M-
dc.creatorAraos, J-
dc.creatorWong, KY-
dc.creatorLeung, YC-
dc.creatorSo, LY-
dc.creatorWong, WT-
dc.creatorCabrera, S-
dc.creatorSilva, C-
dc.creatorAlegria, L-
dc.creatorBruhn, A-
dc.creatorSoto, D-
dc.date.accessioned2018-11-05T01:45:11Z-
dc.date.available2018-11-05T01:45:11Z-
dc.identifier.issn1424-8220en_US
dc.identifier.urihttp://hdl.handle.net/10397/79256-
dc.language.isoenen_US
dc.publisherMolecular Diversity Preservation International (MDPI)en_US
dc.rights© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en_US
dc.rightsThe following publication Andresen, M., Araos, J., Wong, K. Y., Leung, Y. C., So, L. Y., Wong, W. T., ... & Soto, D. (2018). Evaluation of Meropenem Pharmacokinetics in an Experimental Acute Respiratory Distress Syndrome (ARDS) Model during Extracorporeal Membrane Oxygenation (ECMO) by Using a PenP β-Lactamase Biosensor. Sensors (Basel, Switzerland), 18(5), 1-7 is available at https://dx.doi.org/10.3390/s18051424en_US
dc.subjectBiosensoren_US
dc.subjectPenPen_US
dc.subjectPharmacokineticen_US
dc.subjectMeropenemen_US
dc.subjectECMOen_US
dc.titleEvaluation of meropenem pharmacokinetics in an experimental Acute Respiratory Distress Syndrome (ARDS) model during extracorporeal membrane oxygenation (ECMO) by using a PenP Beta-lactamase biosensoren_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage1en_US
dc.identifier.epage7en_US
dc.identifier.volume18en_US
dc.identifier.issue5en_US
dc.identifier.doi10.3390/s18051424en_US
dcterms.abstractIntroduction: The use of antibiotics is mandatory in patients during extracorporeal membrane oxygenation (ECMO) support. Clinical studies have shown high variability in the antibiotic concentrations, as well as sequestration of them by the ECMO circuit, suggesting that the doses and/or interval administration used during ECMO may not be adequate. Thus, a fast response sensor to estimate antibiotic concentrations in this setting would contribute to improve dose adjustments. The biosensor PenP has been shown to have a dynamic range, sensitivity and specificity useful for pharmacokinetic (PK) tests in healthy subjects. However, the use of this biosensor in the context of a complex critical condition, such as ECMO during acute respiratory distress syndrome (ARDS), has not been tested.-
dcterms.abstractObjectives: To describe, by using PenP Biosensor, the pharmacokinetic of meropenem in a 24-h animal ARDS/ECMO model.-
dcterms.abstractMethods: The PK of meropenem was evaluated in a swine model before and during ECMO.-
dcterms.abstractResults: The PK parameters such as maximum concentration (Cmax), elimination rate constant (Ke), and cleareance (Cl), were not significantly altered during ECMO support.-
dcterms.abstractConclusions: (a) ECMO does not affect the PK of meropenem, at least during the first 24 h; and (b) PenP has the potential to become an effective tool for making medical decisions associated with the dose model of antibiotics in a critical patient context.-
dcterms.accessRightsopen access-
dcterms.bibliographicCitationSensors (Switzerland), May 2018, v. 18, no. 5, 1424, p. 1-7-
dcterms.isPartOfSensors (Switzerland)-
dcterms.issued2018-
dc.identifier.isiWOS:000435580300123-
dc.identifier.scopus2-s2.0-85046623817-
dc.identifier.pmid29734646-
dc.identifier.artn1424en_US
dc.identifier.rosgroupid2017006525-
dc.description.ros2017-2018 > Academic research: refereed > Publication in refereed journal-
dc.description.validate201810 bcrcen_US
dc.description.oaVersion of Record-
dc.identifier.FolderNumberOA_IR/PIRAen_US
dc.description.pubStatusPublished-
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