Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/78628
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Health Technology and Informatics | - |
dc.creator | Kong, LH | - |
dc.creator | Wang, Q | - |
dc.creator | Jin, JW | - |
dc.creator | Xiang, Z | - |
dc.creator | Chen, TY | - |
dc.creator | Shen, SM | - |
dc.creator | Wang, HW | - |
dc.creator | Gao, Q | - |
dc.creator | Wang, Y | - |
dc.date.accessioned | 2018-09-28T01:17:07Z | - |
dc.date.available | 2018-09-28T01:17:07Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/78628 | - |
dc.language.iso | en | en_US |
dc.publisher | Public Library of Science | en_US |
dc.rights | © 2017 Kong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | en_US |
dc.rights | The following publication Kong, L., Wang, Q., Jin, J., Xiang, Z., Chen, T., Shen, S., . . . Wang, Y. (2017). Insulin resistance enhances the mitogen-activated protein kinase signaling pathway in ovarian granulosa cells. PLoS ONE, 12(11), e0188029 is available at https://doi.org/10.1371/journal.pone.0188029 | en_US |
dc.title | Insulin resistance enhances the mitogen-activated protein kinase signaling pathway in ovarian granulosa cells | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 12 | en_US |
dc.identifier.issue | 11 | en_US |
dc.identifier.doi | 10.1371/journal.pone.0188029 | en_US |
dcterms.abstract | The ovary is the main regulator of female fertility. Granulosa cell dysfunction may be involved in various reproductive endocrine disorders. Here we investigated the effect of insulin resistance on the metabolism and function of ovarian granulosa cells, and dissected the functional status of the mitogen-activated protein kinase signaling pathway in these cells. Our data showed that dexamethasone-induced insulin resistance in mouse granulosa cells reduced insulin sensitivity, accompanied with an increase in phosphorylation of p44/42 mitogen-activated protein kinase. Furthermore, up-regulation of cytochrome P450 subfamily 17 and testosterone and down-regulation of progesterone were observed in insulin-resistant mouse granulosa cells. Inhibition of p44/42 mitogen-activated protein kinase after induction of insulin resistance in mouse granulosa cells decreased phosphorylation of p44/42 mitogen- activated protein kinase, downregulated cytochrome P450 subfamily 17 and lowered progesterone production. This insulin resistance cell model can successfully demonstrate certain mechanisms such as hyperandrogenism, which may inspire a new strategy for treating reproductive endocrine disorders by regulating cell signaling pathways. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | PLoS one, 10 Nov. 2017, v. 12, no. 11, e0188029 | - |
dcterms.isPartOf | PLoS one | - |
dcterms.issued | 2017 | - |
dc.identifier.isi | WOS:000414866000036 | - |
dc.identifier.eissn | 1932-6203 | en_US |
dc.identifier.artn | e0188029 | en_US |
dc.identifier.rosgroupid | 2017002512 | - |
dc.description.ros | 2017-2018 > Academic research: refereed > Publication in refereed journal | - |
dc.description.validate | 201809 bcrc | en_US |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_IR/PIRA | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Kong_Insulin_Resistance_Mitogen-activated.pdf | 1.87 MB | Adobe PDF | View/Open |
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