Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/77892
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Health Technology and Informatics | - |
dc.contributor | Department of Biomedical Engineering | - |
dc.creator | Tam, BT | - |
dc.creator | Yu, AP | - |
dc.creator | Tam, EW | - |
dc.creator | Monks, DA | - |
dc.creator | Wang, XP | - |
dc.creator | Pei, XM | - |
dc.creator | Koh, SP | - |
dc.creator | Sin, TK | - |
dc.creator | Law, HKW | - |
dc.creator | Ugwu, FN | - |
dc.creator | Supriya, R | - |
dc.creator | Yung, BY | - |
dc.creator | Yip, SP | - |
dc.creator | Wong, SC | - |
dc.creator | Chan, LW | - |
dc.creator | Lai, CW | - |
dc.creator | Ouyang, P | - |
dc.creator | Siu, PM | - |
dc.date.accessioned | 2018-08-28T01:35:27Z | - |
dc.date.available | 2018-08-28T01:35:27Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/77892 | - |
dc.language.iso | en | en_US |
dc.publisher | Nature Publishing Group | en_US |
dc.rights | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | en_US |
dc.rights | © The Author(s) 2018 | en_US |
dc.rights | The following publication Tam, B.T., Yu, A.P., Tam, E.W. et al. Ablation of Bax and Bak protects skeletal muscle against pressure-induced injury. Sci Rep 8, 3689 (2018) is available at https://dx.doi.org/10.1038/s41598-018-21853-5 | en_US |
dc.title | Ablation of bax and bak protects skeletal muscle against pressure-induced injury | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 8 | - |
dc.identifier.issue | 1 | - |
dc.identifier.doi | 10.1038/s41598-018-21853-5 | - |
dcterms.abstract | Pressure-induced injury (PI), such as a pressure ulcer, in patients with limited mobility is a healthcare issue worldwide. PI is an injury to skin and its underlying tissue such as skeletal muscle. Muscle compression, composed of mechanical deformation of muscle and external load, leads to localized ischemia and subsequent unloading reperfusion and, hence, a pressure ulcer in bed-bound patients. Although the gross factors involved in PI have been identified, little is known about the exact disease mechanism or its links to apoptosis, autophagy and inflammation. Here, we report that PI is mediated by intrinsic apoptosis and exacerbated by autophagy. Conditional ablation of Bax and Bak activates the Akt-mTOR pathway and Bnip3-mediated mitophagy and preserves mitochondrial contents in compressed muscle. Moreover, we find that the presence/absence of Bax and Bak alters the roles and functions of autophagy in PI. Our results suggest that manipulating apoptosis and autophagy are potential therapeutic targets for treatment and prevention of PI. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Scientific reports, 27 2018, v. 8, no. 1, 3689, p. 1-11 | - |
dcterms.isPartOf | Scientific reports | - |
dcterms.issued | 2018 | - |
dc.identifier.isi | WOS:000426151800022 | - |
dc.identifier.scopus | 2-s2.0-85042776801 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.artn | 3689 | - |
dc.identifier.rosgroupid | 2017001781 | - |
dc.description.ros | 2017-2018 > Academic research: refereed > Publication in refereed journal | - |
dc.description.validate | 201808 bcrc | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_IR/PIRA | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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Tam_Ablation_Bax_Bak.pdf | 3.18 MB | Adobe PDF | View/Open |
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