Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/7789
Title: The dual roles of Ganoderma antioxidants on urothelial cell DNA under carcinogenic attack
Authors: Yuen, JWM
Gohel, MDI
Keywords: Antioxidants
Bladder cancer
Ganoderma lucidum
Oxidative DNA damage
Yin-Yang
Issue Date: 2008
Publisher: Elsevier
Source: Journal of ethnopharmacology, 2008, v. 118, no. 2, p. 324-330 How to cite?
Journal: Journal of ethnopharmacology 
Abstract: Aims of the study: Ganoderma lucidum possesses significant antioxidant and anti-cancer properties. The effects of Lingzhi antioxidants on oxidative DNA damage and oxidative stress were investigated, in order to understand their roles in bladder chemoprevention. Materials and methods: Antioxidant-enhanced extracts were tested, in terms of ferric reducing antioxidant power (FRAP), 2,2-diphenyl-1-picrylhydrazyl (DPPH·) inhibition, hydrogen peroxide (H2O2) and 8-hydroxy-2′-deoxyguanosine (8-OHdG) concentrations, and cytotoxicity, using an in vitro pre-cancerous human uroepithelial cell (HUC-PC) tumorigenic model. Results: Water-soluble extract (GLw) possesses relatively higher antioxidant capacities than the water-insoluble counterpart (GLe); however, under the challenge of carcinogenic 4-aminobiphenyl (ABP), GLw reduced the 8-OHdG concentration in HUC-PC culture, while GLe induced the formation of H2O2 and 8-OHdG in a dose-dependent manner. The modern theory of antioxidant-oxidant balance seems to obey the theory of Yin-Yang in traditional Chinese medicine (TCM). Conclusions: Water-soluble and water-insoluble components of Ganoderma lucidum exhibited dual roles in oxidative DNA damage. Oxidative DNA damage may be an underlying mechanism of Lingzhi-induced apoptosis in bladder chemoprevention.
URI: http://hdl.handle.net/10397/7789
ISSN: 0378-8741
EISSN: 1872-7573
DOI: 10.1016/j.jep.2008.05.003
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