Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/77543
Title: Synthesis and antibacterial studies of teixobactin analogues with non-isostere substitution of enduracididine
Authors: Jin, K
Po, KHL 
Kong, WY
Lo, CH
Lo, CW
Lam, HY
Sirinimal, A
Reuven, JA
Chen, S 
Li, X
Keywords: SAR study
Ser ligation
Teixobactin analogues
Issue Date: 2018
Publisher: Pergamon Press
Source: Bioorganic & medicinal chemistry, 2018, v. 26, no. 5, p. 1062-1068 How to cite?
Journal: Bioorganic & medicinal chemistry 
Abstract: Teixobactin is a structurally and mechanistically novel antimicrobial peptide with potent activities against Gram-positive pathogens. It contains L-allo-enduracididine (End) residue which is not readily accessible. In this report, we have used convergent Ser Ligation as the key step to prepare a series of teixobactin analogues with End being substituted with its non-isostere moieties. Among these analogues, compounds T16, T27 and T29 exhibited the best antimicrobial activities against different Gram-positive bacteria with MICs ranging from 0.25 to 1.0 µM. Structure-activity relationship is also established for further development of more promising teixobactin analogues.
URI: http://hdl.handle.net/10397/77543
EISSN: 0968-0896
DOI: 10.1016/j.bmc.2018.01.016
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

3
Citations as of Sep 11, 2018

WEB OF SCIENCETM
Citations

2
Citations as of Sep 18, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.