Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/77444
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dc.contributorDepartment of Health Technology and Informatics-
dc.creatorWong, SCC-
dc.creatorCheung, MT-
dc.creatorLuk, LLY-
dc.creatorLee, VHM-
dc.creatorChan, PT-
dc.creatorTsang, HFA-
dc.creatorWong, EYK-
dc.creatorXue, VW-
dc.creatorChan, AKC-
dc.creatorChan, JKC-
dc.date.accessioned2018-08-28T01:32:22Z-
dc.date.available2018-08-28T01:32:22Z-
dc.identifier.issn1949-2553-
dc.identifier.urihttp://hdl.handle.net/10397/77444-
dc.language.isoenen_US
dc.publisherImpact Journals LLCen_US
dc.rightsCopyright: Wong et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0) (https://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.rightsThe following publication Wong, S. C. C., Cheung, M. T., Luk, L. L. Y., Lee, V. H. M., Chan, P. T., Tsang, H. F. A., ... & Chan, J. K. C. (2018). Prognostic significance of Cytokeratin 20-positive lymph node vascular endothelial growth factor A mRNA and chromodomain helicase DNA binding protein 4 in pN0 colorectal cancer patients. Oncotarget, 9(6), 6737 is available at https://doi.org/10.18632/oncotarget.23424en_US
dc.subjectChromodomain helicase DNA binding protein 4 mRNAen_US
dc.subjectCytokeratin 20 lymph nodeen_US
dc.subjectPrognostic significanceen_US
dc.subjectVascular endothelial growth factor A mRNAen_US
dc.titlePrognostic significance of Cytokeratin 20-positive lymph node vascular endothelial growth factor A mRNA and chromodomain helicase DNA binding protein 4 in pN0 colorectal cancer patientsen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage6737-
dc.identifier.epage6751-
dc.identifier.volume9-
dc.identifier.issue6-
dc.identifier.doi10.18632/oncotarget.23424-
dcterms.abstractBACKGROUND: Cytokeratin 20-positive cells in lymph nodes from pN0 colorectal cancer (CRC) patients were detected previously by us. The aims of this study were to investigate which tumor metastasis-related genes were involved and their potential clinical significance. RESULTS: Fourteen of 84 (17%) genes were differentially expressed by at least 2-fold. Among them, 10 genes were up-regulated whereas 4 genes were downregulated. Those differential expressed genes were validated in the second cohort of specimens. Follow-up analysis for 60 months showed that patients with lymph node vascular endothelial growth factor A (VEGF-A) mRNA and chromodomain helicase DNA binding protein 4 (CHD4) mRNA expression higher than the median copies had significantly shorter time to recurrence than those with lower than the median copies. Multivariate analysis showed that VEGF-A mRNA, CHD4 mRNA and lymphatic vessel involvement were independent prognostic factors for disease recurrence. CONCLUSIONS: VEGF-A mRNA and CHD4 mRNA were up-regulated in CK20- positive pN0 lymph nodes and they may have prognostic significance in pN0 CRC patients. METHODS: Two cohorts of lymph node specimens from pN0 CRC patients of each with and without CK20-positive cells were recruited. In the first cohort, tumor metastasis genes were profiled using gene expression arrays. Differential expressed genes were validated in the second cohort. Moreover, their prognostic significance was examined by following-up the second cohort of patients with CK20-positive cells for 60 months and all histopathological findings were correlated to recurrence.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationOncotarget, 2018, v. 9, no. 6, p. 6737-6751-
dcterms.isPartOfOncotarget-
dcterms.issued2018-
dc.identifier.scopus2-s2.0-85040941330-
dc.identifier.rosgroupid2017003853-
dc.description.ros2017-2018 > Academic research: refereed > Publication in refereed journal-
dc.description.validate201808 bcrc-
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_IR/PIRAen_US
dc.description.pubStatusPublisheden_US
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