Method for asymmetric alkynylation of alpha-imino esters

Abstract

Method for the preparation of asymmetric alkynylated alpha-amino esters of the formula wherein R1 and R2 are independently optionally substituted alkyl cycloalkyl, aryl or heteroaryl, and Y is hydrogen or a nitrogen protecting group. 本发明涉及一种式III的不对称炔基化的α-氨基酯的制备方法，其中R1和R2独立地为任选取代的烷基、环烷基、芳基或杂芳基，且Y为氢或氮保护基。