Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/76820
Title: Pathological role and diagnostic value of endogenous host defense peptides in adult and neonatal sepsis : a systematic review
Authors: Ho, J
Zhang, L
Liu, X
Wong, SH
Wang, MHT
Lau, WM 
Ngai, SPC 
Chan, H
Choi, G
Leung, CCH
Wong, WT
Tsang, S
Gin, T
Yu, J
Chan, MTV
Wu, WKK
Keywords: Antimicrobial peptides
Cathelicidin
Defensin
Hepcidin
Systemic inflammation
Trauma
Issue Date: 2017
Publisher: Lippincott Williams & Wilkins
Source: Shock, 2017, v. 47, no. 6, p. 673-679 How to cite?
Journal: Shock 
Abstract: BACKGROUND: Sepsis is a systemic host response to an infection leading to organ failure. This is associated with dynamic expression of endogenous host defense peptides. Dysregulation of these peptides is associated with septic morbidity and mortality.
METHODS: We performed a systematic search of articles indexed in PubMed, ISI Web of Knowledge, EmBase, and Scopus database from inception to October 2016. Both preclinical and clinical studies investigating the role of host defense peptides in pathogenesis and as biomarkers for sepsis were included.
RESULTS: Of the available literature, cathelicidin, defensin, and hepcidin are among the best-characterized peptides. These regulate immune response, and crosstalk with pyroptosis and coagulation cascades. The applicability of these peptides as septic biomarkers has been investigated in vitro and in vivo studies. However, numerous studies were based on endotoxemia without an infection, jeopardizing interpretation of the outcomes. Cathelicidin and defensin were frequently reported in adult sepsis while hepcidin in neonatal sepsis. The expression level of these peptides is significantly associated with septic condition. Most of the studies employed a cross-sectional design, precluding the establishment of a temporal relationship between candidate peptide biomarkers and sepsis.
CONCLUSIONS: Innate defense peptides have been insufficiently evaluated as either diagnostic or prognostic biomarkers. In the future, evaluation of host defense peptides as septic biomarkers may employ a longitudinal design and consider a panel of multiple peptides.
URI: http://hdl.handle.net/10397/76820
ISSN: 1073-2322
EISSN: 1540-0514
DOI: 10.1097/SHK.0000000000000815
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